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How does GcMaf work?

Discussion in 'GcMAF' started by everhopefulme, Apr 27, 2014.

  1. everhopefulme

    everhopefulme

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    I need a very short yet effective explanation of how gcmaf works and I seem to remember reading on this site a very concise and succinct explanation, given by the late great Rich Van K, but I can't now find it, can anyone point me in the right direction please? The gcmaf DN website is suitably vague and other websites such as http://www.nagalasebloodtest.com/more-information-concerning-nagalase.html is too complicated for what I need. Thankyou
  2. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    This may be too simple! But...GcMAF activates macrophages.

    In some patients the natural ability to activate macrophages is blocked by high levels of nagalase or, macrophages are being activated by high levels of LPS (Lipopolysaccharides)--which has a negative effect.

    Injecting macrophage activating factor (GcMAF) bypasses this and, over time, reduces nagalase and enhances the ability of the immune system to fight pathogens. You can find more useful information at GcMAF.eu.

    Best,
    Sushi
  3. everhopefulme

    everhopefulme

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    I seemed to remember that he said something along the lines of the following:
    Pathogens protect themselves from the body's defense system by producing nagalase which deactivates the gcprotein in the liver. This then cannot convert to gcmaf, which is the signalling mechanism for macrophages to attack the incoming viruses. So by giving extra gcmaf this then attacks the pathogens whose nagalase is then reduced to the point where the body can fend for itself.

    I really would like to have this right as a friend who is thinking of trying it has asked me how it works and I can't find a suitable explanation for her. Am I on the right track here?
  4. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    Yes, this is the right track. If your friend wants to try GcMAF, testing nagalase levels is somewhat predictive of how well GcMAF will work for him/her. It is also important to test things like inflammatory cytokines--especially IL 8-- and things like C4a and sCD14. If these are too high, your friend might have a hard time with GcMAF. Also, be aware that the usual dosing recommendations are suitable for cancer or HIV but are too high for most ME/CFS patients.

    Starting on a fairly low dose (that is if other tests support the use of GcMAF)--say 10 - 25 ngs is safer than trying the usual dose of 100 ng, which can cause IRIS. Some find that they can tolerate more, some less.

    Here is one quote from Rich where he was summarizing for me, KDM's talk on GcMAF at a 2011 Conference at Mt. Sinae:

    Sorry, I do not have a direct link to his comments.

    Sushi
  5. everhopefulme

    everhopefulme

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    Thanks Sushi that 's really helpful.
  6. JalapenoLuv

    JalapenoLuv *****

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    unknown
    No point reinventing the wheel. Gcmaf is replacement therapy for a molecule destroyed by an enzyme that virus's and cancers make. If the molecule isn't present immune system function decreases 40x.

    Best info on it.
    http://gcmaf.timsmithmd.com/book/book/2/

    However, Gcmaf isn't the only player in CFS. Most CFS patients have epstein barr virus (EBV) and some will also have bartonella (mental symptoms-irritability, anxiety, depression). Both of these infections are potent immune blockers.

    So if you have these infections and don't have a way to disable the immune blocking the immune system shouldn't be able to recover and the Gcmaf therapy shouldn't work. I think this might account for why some people get better and others don't. This is my experience as a CFS patient with chronic bartonella and EBV.

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