I notice that when I've overdone it or when I'm having a viral infection or even a flare I get terrible depression. The depression is almost worse than the mood symptoms. I know there are neurological issues and I'm sure my hormones are a mess (waiting on test results) but nothing I'm doing helps the mood symptoms. I just got taken off Valcyte because my liver enzymes were elevated. I was on it for 7.5 months and the mood symptoms started while on Valcyte. What do you all do when you're in that dark place? The depression plus the isolation is really getting to me. I'd be willing to try an antidepressant but while my liver enzymes are whacked I'm guessing I need to wait?