1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
9th Invest in ME International ME Conference, 2014 - Part 2: Pathogens and the Gut
Mark Berry continues his series of articles on the 9th Invest in ME International ME Conference in London, with the emphasis shifting from autoimmunity to pathogens and the gut ...
Discuss the article on the Forums.

HOT! Coffin, Sharma, and Goff@ Conference on Retroviral Infections...

Discussion in 'Media, Interviews, Blogs, Talks, Events about XMRV' started by parvofighter, Feb 20, 2010.

  1. Michelle

    Michelle Decennial ME/CFS patient

    Messages:
    104
    Likes:
    10
    Portland, OR
    I've been a member here for a long time but don't get a chance to post much because I'm generally too sick and take way too long to process information anymore. But thank you. Thank you so much for posting this, Parvofighter. And you too, Advocate, for posting the link to the MedPage Today article. I'm trying not to get too excited yet about XMRV. I keep repeating to myself they have not yet proven that XMRV causes ME/CFS like it were a mantra. But...damn. Reading that it appears to be replicating in the GI tract and reproductive organs is just freakin' fascinating.

    I started getting sick when I was 10-11. It wasn't too severe (lots of respiratory infections) but by 12 I had IBS. I got very ill when I had surgery 11 years ago and had a GI infection. Had another nasty GI infection 6 years ago and have been in horrible pain since. I've had unusual UTIs over the last several years as well as pain in my lower right abdomen for which my doctor wants me to get a laproscopy. I had blood clots in my lungs three years ago (for which I'm now on Coumadin) and they have no idea why. For that pain in my lower right abdomen they put me on progestrone-only birth control. I haven't had a good day since, except when I first started DHEA (but that only lasted for a month and a half).

    I'm rambling about a bunch of possibly unconnected items. It's too easy to see my symptoms through this new XMRV lens. But...oh, could it really be possible that this new lens is the right one? Sigh. Only time and research will tell.

    They have not yet proven that XMRV causes ME/CFS ...
  2. dmarie4301

    dmarie4301 Guest

    So, they really infected monkeys with XMRV???? Really??? Did I get that right?

    This forum never ceases to amaze me at how quickly you jump on the latest news!

    So, separate from the WPI work, a lab infected monkeys with XMRV, they got sick and they found the XMRV in lymph and sex organs???? Is this really true???

    Did I get that right??? That is incredible!!! That's proof that XMRV is an infectous agent!

    (I am wanting confirmation on this guys and gals..Im getting this right, right?? How come WPI hasnt mentioned this study?)

    Also, I was blown away when Dr. Goff said that, when cultured, XMRV is VIGOROUS!!!!! VIGOROUS was the word he used. Not low level, not small quantities, not hard to find.....but it's vigorous!!

    It seems everyday now, there is something to keep an eye on!!!

    Thanks Cort for starting this website and the forums, it's been and is one of the most useful resources Ive ever run across in 20 years.

    Donna
  3. Advocate

    Advocate Senior Member

    Messages:
    506
    Likes:
    14
    U.S.A.
  4. julius

    julius Watchoo lookin' at?

    Messages:
    785
    Likes:
    5
    Canada
    They didn't get 'sick'. They simply got infected.

    Also, the study isn't completed or published yet. So WPI probably won't make any official statement.
  5. dmarie4301

    dmarie4301 Guest

    Well, you know what I mean. The monkeys were acutely and chronically infected is what she said. Advocate just posted the abstract. Fascinating:
    http://www.retroconference.org/2010/Abstracts/39393.htm
  6. Cort

    Cort Phoenix Rising Founder

    Messages:
    7,025
    Likes:
    439
    Raleigh, NC
    It does show that XMRV can infect numerous parts of the body; that it you get it in the blood it can go on and infect cells in the lymphoid organs, lungs, reproductive tissue (what about the brain?). It doesn't say that its causing problems in any of these but its definitely infecting cells in our good friends (poor guys) the primates. I think that's pretty big news. It also shows how serious these researchers; primates are alot more expensive than rodents; they 'harvested' them at two weeks and over a couple of months - expensive stuff I imagine.

    They didn't appear to get ill though - interesting - but probably not very conclusive. I think people with HIV typically feel like they come down with a cold (or not) and then appear to recover and are fine for years! I think retroviruses often take alot of time to do their work.

    I think everyone should follow Michele's lead.

    First a replication study that finds something!
    Then a study that indicates removing or inhibiting the virus brings results.
    (Then get really excited. :))
  7. dmarie4301

    dmarie4301 Guest

    Dr. Mikovits said during her Q&A with Cheney on Feb 20th, that yes, she believes it could infect the brain. I am impressed that they have taken this virus and gone as far as infecting monkeys, I agree Cort. Im also very pleased that it's a separate study from WPI's work. AND that it is a different type of research. Looks like perhaps it could lead to a serology test as well. Im very pleased that other entities besides WPI really are taking this seriously.
  8. fairlight

    fairlight

    Messages:
    77
    Likes:
    0
    I had a stomach biopsy done several weeks ago. I wonder if they can check it for XMRV?
  9. julius

    julius Watchoo lookin' at?

    Messages:
    785
    Likes:
    5
    Canada
    I've been wondering about the notion that these monkeys aren't getting sick. How did they determine that? Does anybody know?

    Seeing the monkeys can't talk (presumably) the only way one could tell if they are sick is through observation, and/or testing. We all know that observation and testing doesn't really show illness with CFS. Unless you get very specific testing, of severe CFS.

    Maybe they are sick and the researchers just can't tell.
  10. dmarie4301

    dmarie4301 Guest

    Good point. I was assuming they were sick, if they have XMRV....and if we have it too, and it is the causation of our misery, then they would feel sick. A lot of assumptions. But yeah, did they take their temps to see if there was an initial fever? Im not sure now what she meant that they were acutely and chronically ill.

    Nevertheless, it certainly is an interesting twist of news....that they found the virus in different tissues, post mortem. Dr. Mikovits has been saying all along that they need more research to find tissue reservoirs....is the XMRV in other tissue besides blood?

    I would guess the monkeys werent feeling well tho. :)
  11. Lynn

    Lynn Senior Member

    Messages:
    301
    Likes:
    51
  12. usedtobeperkytina

    usedtobeperkytina Senior Member

    Messages:
    1,384
    Likes:
    185
    Clay, Alabama
    Cort, I read the same thing about how HIV develops.

    Tina
  13. SeaShel

    SeaShel Senior Member

    Messages:
    111
    Likes:
    0
    AZ
    My pea brain is in overdrive with this news.

    Did my total hysterectomy several years ago inadvertently help me? Or make things worse cuz the xmrv (if I have it) has to find somewhere else to hang out? (can that happen?)

    This did make me connect a couple of dots for myself when I realized tonight that it's been since the hysterectomy that I quit having the constantly swollen lymph nodes.

    Hmmmmm - so many questions!

    Shelley
  14. FernRhizome

    FernRhizome Senior Member

    Messages:
    412
    Likes:
    0
    SeaShel:
    I bet it helped....it's known that menstral cycling exacerbates CFIDS symptoms.
  15. beesknees

    beesknees Senior Member

    Messages:
    116
    Likes:
    0
    Is it possible the monkey isn't showing signs of being ill because it hasn't been introduced to a secondary infection. Doesn't XMRV need a secondary infection to activate among other things. Most of us got sick after Glandular Fever, Mono, Lyme, etc. That explains why some people that test positive for XMRV don't have symptoms. I wonder if they have plans to do that? Here's a stupid question would it make a difference if they infected a male monkey or a female monkey?
  16. gracenote

    gracenote All shall be well . . .

    Messages:
    1,508
    Likes:
    42
    Santa Rosa, CA
    beesknees, that's an interesting question.
  17. camas

    camas Senior Member

    Messages:
    697
    Likes:
    196
    Oregon
    They did mention finding XMRV in the vaginal tissue of the one female monkey, but didn't mention if she was more severely infected.
  18. Marco

    Marco Old blackguard

    Messages:
    1,275
    Likes:
    953
    Near Cognac, France
    OK. Who forgot to sexually abuse the monkeys?;)
  19. Kati

    Kati Patient in training

    Messages:
    1,964
    Likes:
    1,278
    Good one Marco, quirky!!!
  20. flybro

    flybro Senior Member

    Messages:
    581
    Likes:
    5
    pluto
    SeaShell I definately benefited from having a hysterectomy about 18yrs ago, my ovaries were aspirated to get rid of cysts. I wish I had got rid of my ovaries too.

    I'm still considering binning the ovaries as cycsts continue to be a prob.

See more popular forum discussions.

Share This Page