I've just had a methylation panel done with a local Australia pathology lab (NutriPath). The results aren't overly promising. Click here for the report. I'm currently on: 3 mg of Solgar Metafolin 1 pump of B12oils methylcobalamin 1 mg of AOR Sublingual Methylcobalamin 1/2 cap of Metabolics B Complex twice daily Other less important supplements (too lazy to list ) There appears to be a block causing SAH to accumulate in the methylation cycle and a block in the folate cycle causing THF and folinic acid to accumulate. Before starting on methylation treatment my normal homocysteine was 6.5 umol/L (0.0-15.0), it has now risen to 9.5 umol/L. It should have been high to start with, so there was obviously a block in conversion from SAH to homocysteine which has been relieved somehow with methylfolate and methylcobalamin. I've been undergoing treatment this time for about 2 1/2 months. I was suggested TMG, but this causes immediate improvement for an hour or two then the worst imaginable crash even at tiny doses. Any ideas? Thanks.