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Horizontal transmission of murine retroviruses - saliva etc

Discussion in 'XMRV Research and Replication Studies' started by natasa778, Mar 6, 2010.

  1. natasa778

    natasa778 Senior Member

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    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC254060/?report=abstract

    Abstract
    Both a feral mouse ecotropic virus (WM-E) and Friend ecotropic virus (F-MuLV) were transmitted horizontally among adult mice. Infection resulted in the production of antiviral antibody in the recipients, with no evidence of viremia or clinical disease. However, persistent low-level virus replication was detectable in the spleens of these mice as long as 8 months after initial infection. External secretions, including saliva, semen, and uterine secretions from viremic mice contained high concentrations of infectious virus. Nevertheless, transmission occurred only from viremic males to either males or females. Male-to-male transmission appeared to occur by parenteral inoculation of infectious saliva during fighting behavior. Evidence is presented that infection of females was by the venereal route. Of four mouse strains examined, NFS/N, IRW, and C57L females were all susceptible to venereal infection, whereas AKR mice were not. Since AKR mice are susceptible to infection by WM-E administered parenterally, this resistance appeared to be mediated by local viral interference due to the high-level expression of endogenous Akv gp70 within the female reproductive tract. Although both WM-E and F-MuLV were transmitted from viremic males to females, infection by WM-E was significantly more efficient than that by F-MuLV. This difference correlated with a distinct difference in cellular tropism of WM-E and F-MuLV within the epididymis of viremic males. F-MuLV gp70 was expressed only within stromal elements, whereas WM-E gp70 was seen largely within the epithelial lining cells and luminal contents of the duct. No evidence of virus expression within germ cells was observed. The possible influence of virus expression by epithelial cells of the female reproductive tract on infection of embryos is discussed.
     
  2. Psyma

    Psyma

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    infectious blood to blood
    or
    infectious saliva to blood
    or
    infectious saliva to saliva


    This article doesnt really show anything new about saliva
     
  3. omerbasket

    omerbasket Senior Member

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    But look at this interesting quote:
    As far as I know, "viremia" means "virus in the blood". Meaning that they are saying that only males with virus in the blood infected other males or females. So, if you have the virus in the spleen, but you don't have it in the blood, according to this study, and while assuming that the virus that you have feral mouse ecotropic virus (WM-E) ore Friend ecotropic virus (F-MuLV) and that you are a mouse, you won't infect others.

    I don't fully understand that quote. Does it say that saliva appeared to be able to infect other mice, but only if the saliva touched the blood? So, does it say that if the mouse drank from a glass and spit into it, and another mouse than drank from the same glass without washing it first, that other mouse might very well not be infected? But it he took that saliva and put it on an open wound he is risking getting infected?
     

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