So I've been browsing this site quite a bit, I'm not sure how I never came across this site before, well apparently I signed up but never used it. Anyway sorry this is kinda long, I figured I'd try to explain enough as possible and see what people might think. Am open to any and all ideas in the road to recovery so if you have anything at all you feel like might be of help feel free to respond. I'm not even sure I really have cfs but I feel like it's the closest thing. The biggest things are... huge mental fatigue extreme apathy physically my fatigue isn't too bad, unless I overexert myself. I can normally run for a little while and be fine. hyper vigilant... I'm always feeling wired and tired. Startle response is extreme, it's gotten to the point now where even if someone just grazes me, I have a started reflex. persistant cough/ sore throat but that seems to have only developed in the past year and comes and goes unrefreshing sleep, and also insomnia Very sensitive to supplements, think I have high histamine, have hives a lot, and many foods that are acidic, (do not do well with things with lemons or vinegar unelss in small amounts) b12 specfically seem to be too stimulating and worsens my insomnia, same with magnesium, vitamin c, and some other ones. I actually do seem to tolerate b6 well and helps with the sore throat and high histamine symptoms, as long as I don't take too high a dose. methyfolate I can't really tell if it does anything, been taking it for months, take a 5mg dose everyday. I would say at the beginning which was about 5.5 years ago things were at the worst.. they didn't get any better and I was hardly functional till I really started eating very healthy (low carb, gluten free, a very balanced diet). I seem to tolerate alcohol fine, I can drink quite a bit, which I'm not sure if that means anything, like shouldn't my ability to detoxify be hindered? I dunno. From reading my dna results from genetic genie I am heterozygus for a1298c I have no mutations on c677t then my other mutations Here are your homozygous mutations as indicated in your SNP gene table above (not including MTHFR): MAO-A R297R MTRR A66G CBS A360A Here are your heterozygous mutations as indicated in your SNP gene table above (not including MTHFR): VDR Bsm VDR Taq MTRR A664A BHMT-02 BHMT-08 Also according to my promethease report I have a "2 - 4 fold increased odds of developing V617F-positive MPN A Promethease user who has this rs12340895(G;G) genotype has reported that they have mastocytosis" ... which makes a lot of sense considering how bad I react to things. So from what I've read I have a predisposition to having higher levels of ammonia and low bh4. I've read a lot about it and am thinking of cutting out protein and sulfur foods... Has anyone have experience with this? Anyway thanks for reading and would definitely appreciate any and all advice, even if it doesn't apply directly to this I am always open to new ideas and love learning.