I tried some inosine today, and seemed to feel better from it, with slightly less fatigue and a seeming reduction in swollen gland feeling. I got a little nauseated this afternoon though, not sure if it was from that or something else. I think I'll try it again tomorrow. Aside from possibly being an immune modulater, the uric acid formed from the inosine is supposed to be a potent scavenger of peroxynitrite, which, if true, I would suspect to be the cause of immediate small improvements rather than any changing the immune system, which I would suspect could take longer. But that's just a guess. My WBC is chronically low (<3.5-4) ever since first having the chemical injury that started all these health problems, but I haven't had it tested since this immune aspect of the chronic fatigue happened. I was getting it tested every 3-4 months to track the thyroid levels (I developed hashimoto's a couple years ago also, from the immune problems related to the chemical injury), but since getting CFS I don't know if I'll get tested again. If I don't start improving I think I'll just let the thyroid worsen until it kills me rather than live with this level of CFS for the rest of my life. It's just not worth it. If I do get tested again while on the inosine, I'll try to remember to post the results here. If you want to raise NK and cytotoxic T cells, the medicinal mushrooms might be good to try (reishi, maitake, shiitake, cordyceps, etc.) Those are known to raise NK cells. I also found this yesterday on medline, a chinese herb called Tai Zi Shen (Pseudostellariae). I think it might be worth a try.