An ME Association news post about a photography project on ME (interesting in itself) includes this: "The crux of the research being carried out at Newcastle University involves looking for the biological marker that predicts chronic fatigue. Professor Newton and her colleagues are investigating whether certain parameters highlight chronic fatigue and will use this knowledge to help devise simple, non-invasive treatments to improve patient's lives. Over half of the patients they have studied showed dramatic changes in blood pressure or increased heart rate when they stood up. Although most people will show some change, it is a marked difference in patients with ME. Professor Newton believes the problem could go way back - to when we evolved to stand upright thousands of years ago. "We used to have our heart and head in line and now we're upright, it looks likely that some people have physically evolved more successfully than others and can therefore cope better with the move from sitting to standing. It is a physiological response to the stress of standing up, as not enough blood is getting to the muscles." One of the ways Professor Newton and her team have been helping people with ME is through the use of HOT (Home Orthostatic Training). This process mimics the tilt tables used at the University but does not need any specialist equipment, so is easy and cost effective to use. It works by resetting the pressure receptors in the body, through a series of simple exercises. " Anyone know anything about HOT?