I've been on subcutaneous hizentra now for 2 months. I was prescribed hizentra because of blood markers indicating a dysfunctional immune system. Other associated issues include a reactivation of EBV and HV6, numbers are higher on the EBV. My salivary glands directly under my jaw have been enlarged for over 2 years and at times there is corresponding pain in my cervical neck lymph glands. I have come across references that indicate hizentra is prescribed by several ME/CFS doctors including Klimas. My doctor specializes in ME/CFS and I have struggled with it for 15 years the last 3 have left me living in my bed or on my sofa. At about 4 weeks in I did have a couple of improved days and have continued to have a few days per week that are marginally improved. Some of the side effects from hizentra for me include an increase in muscle pain in my legs and an increase in pressure and pain at the base of my skull. I am having some increase in cognitive problems and at times an increase in episodes of depression. These I want to believe are positive indications, maybe my immune system is doing something. I would love to start a conversation on hizentra and its efficacy. Who else is using hizentra and what effect is it having on your symptoms. If it helped, when did you notice the improvement? Can it be used in combination with an antiviral? Any comments or observations are welcome.