Seems we need some but not too much. I've had some very positive results with supplements that mess with histamine one way or another (Niacin a couple of years back, Dao enzyme and recently my Ester C with Rutin and Hesperedin, and SMP). I've had enough positives with Histamine supps to believe I need to really dive into this. Something at work here but it's very dynamic making it hard to pin down. I found this article today that indicates Salt as an anti-histamine also impresses the importance of taking Salt with Potassium: "A good example is orange juice. Orange juice is loaded with potassium that our body cannot use without salt. * So when a person drinks orange juice and does not take enough salt that is required for the potassium to go into the human cell, then histamine is released to take care of this problem" I've looked into the mast cell information posted here already and tried the Mast supplements like luteolin and NeuroProtek. I would love to hear from those of you that have mastered/researched histamine.