Well, I'm not posting this to prevent anybody from taking Vitamin D. It's just very interesting, that things often are very complicated in medicine. How often have we heard, that vitamin D is very good for us? In my eyes, vitamin D was one of the most promoted supplements during the last years. Vitamin D is important, no doubt about it but there is no guarantee whatsoever, that vitamin D supplementation will benefit the individual patient. This was the study with the largest sample size up to today, which looked at Vitamin D and eczema. The results were not what we would expect. Higher vitamin D levels are connected to a higher prevalence of eczema, while the lowest Vitamin D levels were connected to significantly less eczema. It would be very interesting to know the causality behind it. http://www.ncbi.nlm.nih.gov/pubmed/23751100 Allergy. 2013 Jul;68(7):906-10. doi: 10.1111/all.12167. Epub 2013 Jun 10 Heimbeck I, Wjst M, Apfelbacher CJ. Source Medical Sociology, Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany. Abstract BACKGROUND: Recent studies have yielded heterogeneous results regarding the relationship between vitamin D and atopic conditions. The aim of this study was to investigate the association between serum vitamin D level and the prevalence of eczema in German children and adolescents. METHODS: Data were drawn for children aged 1-17 from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS), a nationwide cross-sectional representative survey. 25-hydroxyvitamin D (25(OH)D) serum concentration was measured in 9838 individuals with eczema and categorized into quartiles. We investigated the association of vitamin D level and eczema by means of logistic regression models. RESULTS: Weighted prevalence of eczema was 13.5% (95% confidence interval (CI) 12.6-14.4%). Mean vitamin D level was significantly higher in those with eczema compared with those without (P < 0.0001). Logistic regression revealed an inverse association between low levels of vitamin D and eczema (multivariate OR for quartile 1 vs quartile 2: 0.76 (95% CI 0.61-0.94)). CONCLUSIONS: This study suggests that low serum vitamin D level is inversely associated with eczema in German children and adolescents. Prospective studies are required to confirm this result, to discuss a potential opportunity for prevention of eczema. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.