Just got back a both a serum and urine amino acid profile. One of the results was very high urine sarcosine 70.3 (0.3-27.3) and high plasma sarcosine 6.3 (0.0-4.0). But my urine and plasma glycine levels are normal. Moreover my plasma methionine levels are 33.6 (0-41). My urine methionine levels were middle of the range more or less (though urine is not considered as useful as plasma for methionine). As per this reference http://www.metametrixinstitute.org/file.axd?file=2008/12/Page-234.pdf I am taking 100 mg of b2 a day and my iron levels have been fine (both serum and ferritin) for some time now. So unless there is a depletion of THF the sarcosine to glycine reaction should be open and clear. But as I said my methionine levels are high normal. Then again my homocysteine is a 10.0. On the other hand maybe my SAMe / SAH ratio is too high and the Glycine N-methyltransferase enzyme is working over time and trying to drive the equilibrium gradient backwards. As I said though my glycine levels are heart of the range even despite me supplementing 8-10 grams at bed time. Also I should point out I ingest a lot of protein each day (like 240 grams / day). So I am not sure what to make of this. I was also high normal to slightly elevated in BCAAs which would fit my catabolic issues. Amino-adipic acid was also high but that may be due to high normal lysine and my taking high amounts of B3 (500 mg early and 250 mg at bedtime). I wonder if a possible high SAM / SAH ratio is the reason why I like the niacinamide? Anyways let me know your thoughts. I wonder if it time to get a HDRI methylation panel and find out which side of the 8-ball I am right now. Anyone have any other methylation panels they prefer? I had a NutraEval a couple of years ago which was useful for some things but not particularly for methylation / folate cycle from what I could tell. Thanks.