1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Dr. Kerr, I presume?
Clark Ellis brings us a rare interview with British researcher Dr. Jonathan Kerr who is now living in Colombia.
Discuss the article on the Forums.

High Prolactin Causes Severe Fatigue.

Discussion in 'Hormones' started by Ema, Jul 7, 2013.

  1. Ema

    Ema Senior Member

    Messages:
    3,428
    Likes:
    3,818
    Midwest USA
    I just took one! I hope I don't get nausea or fainting. I hate both of those!

    So here is an article that says that the formulation does make a difference.

    "The formulation of bromocriptine is also important. In these clinical studies, 5 out of 6 studies that showed clinical benefits used RR-bromocriptine.20–24 The one study that used an ordinary form of bromocriptine showed no benefit.25 Since “fine tuning” seems important for effects on hypothalamic circadian rhythm, RR-bromocriptine may be required to meet the concept and hypothesis of improved glucose and energy metabolism through CNS mediation."

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047985/

    The studies were all pretty small though.

    Wish me luck!

    Ema
     
    roxie60 and heapsreal like this.
  2. Ema

    Ema Senior Member

    Messages:
    3,428
    Likes:
    3,818
    Midwest USA
    Well, goodness, this has all been very anti-climactic so far (knock wood).

    I wonder if I should go straight on to 1.6 mg tomorrow?
     
  3. Ema

    Ema Senior Member

    Messages:
    3,428
    Likes:
    3,818
    Midwest USA
    Maybe not so anti-climactic...second day at 0.8, I do have nausea, headache and a lot of fatigue. It's discouraging but not unexpected since the side effects were so widely reported. Sucks to feel like crap again though when I was just starting to feel normal-ish again...I hope it is worth it!

    Ema
     
    roxie60, heapsreal and vli like this.
  4. Rand56

    Rand56 Senior Member

    Messages:
    491
    Likes:
    173
    Myrtle Beach, SC
    hi Ema

    Sorry you're feeling like crud :(. Maybe try taking it this way? :thumbsup:......

    "Adverse effects occur in over 50% of women taking oral bromocriptine, causing at least 10% to discontinue treatment. Although the drug is absorbed from the vagina and reportedly caused no side-effects in one patient intolerant of oral bromocriptine, long-term clinical effects of daily vaginal administration have not been assessed. We have now given bromocriptine vaginally for up to 2 years to 31 hyperprolactinemic and five normoprolactinemic women, 17 of whom were intolerant of oral bromocriptine. The drug was well absorbed from the vagina and a daily dosage of 2.5 mg lowered serum prolactin levels in 28 of the hyperprolactinemic women (in 11 to within normal limits), restored menstrual cyclicity, and abolished galactorrhea; one of the four infertile women conceived. Minor side-effects occurred in only three women. Vaginal administration is clinically effective, avoids the adverse effects of oral therapy and could be the first-line treatment for patients requiring bromocriptine."

    http://www.ncbi.nlm.nih.gov/pubmed/1502929

    Rand
     
  5. Ema

    Ema Senior Member

    Messages:
    3,428
    Likes:
    3,818
    Midwest USA
    Interesting! I might give that a try...wonder if it works with Cycloset as well as the regular bromocriptine? I'll have to check out the Krazy Kruse forums...

    Thanks!
    Ema
     
  6. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    7,320
    Likes:
    4,678
    australia (brisbane)
    i wonder if normal bromo might be different because it isnt absorbed as fast or what u have mentioned early, not as much absorbed either?? worth a shot.
     
  7. Ema

    Ema Senior Member

    Messages:
    3,428
    Likes:
    3,818
    Midwest USA
    I'll keep at it for another week or so at least. I've waited so long to try this med that I can't see giving up already. I just wanted to whine a little bit about feeling crappy. :)

    I might try the cabergoline if I can't stand the bromocriptine. I think you only have to take that once or maybe twice a week.
     
    roxie60 and vli like this.
  8. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    7,320
    Likes:
    4,678
    australia (brisbane)
    even some of the meds used for restless leg syndrome might have a different effect. I think i recall reading where one of these types of dopamine agonists helped fibro??
     
  9. vli

    vli

    Messages:
    1,955
    Likes:
    2,051
    CA
    I'm on the caber... yeah only twice a wk...
     
    heapsreal likes this.
  10. xks201

    xks201 Senior Member

    Messages:
    618
    Likes:
    186
    Tried caber and pramipexole...prefer caber...it's easy to OD on these drugs. Oding on prami by .1mg will make you extremely nauseous, dizzy, and tired.
     
  11. anne_likes_red

    anne_likes_red Senior Member

    Messages:
    839
    Likes:
    259
  12. Ema

    Ema Senior Member

    Messages:
    3,428
    Likes:
    3,818
    Midwest USA
    I haven't noticed anything like what she describes with the Cycloset. Sure wish I had! I've only noticed nausea, headaches, OI and increased fatigue. Makes me jealous!

    Ema
     
  13. Ema

    Ema Senior Member

    Messages:
    3,428
    Likes:
    3,818
    Midwest USA
    I'm really seriously considering trying it this way. Wish I could find just one person that had done it though! I have posted on the Kruse forums. We'll see!

    Ema
     
  14. Ema

    Ema Senior Member

    Messages:
    3,428
    Likes:
    3,818
    Midwest USA
    Kruse replied to my post on his forum and said Cycloset could be used vaginally.

    Thanks for the tip, Rand56!
     
    Rand56 and anne_likes_red like this.
  15. roxie60

    roxie60 Senior Member

    Messages:
    1,686
    Likes:
    532
    Central Illinois, USA
    Interesting. I believe that is the fourth thing the Dr is testing today. She mentioned something about a tumor. I know nothing about this test so I need to do some research. All my neurotransmitters have been low to very low, my estridiol, progesterone and testosterone were/are low (now being treated with estridiol and just started progesterone (BI) last week. Will be interested to see what the prolactin result is. There seem to be so many things that can cause so many of our symps, no wonder we, doctors and family/friends get worn out chasing answers.
     
  16. roxie60

    roxie60 Senior Member

    Messages:
    1,686
    Likes:
    532
    Central Illinois, USA
    Prolactin ranges
    Adults
    Female
    2.8-29.2
    Nonpregnant: 2.8-29.2
    Pregnant: 9.7-208.5
    Postmenopausal: 1.8-20.3
     
  17. Beyond

    Beyond 10% of discount in iHerb!--> PEZ915

    Messages:
    937
    Likes:
    520
    Murcia, Spain
    The reference range for men is 2 -18. Mine has consistently been in ranges 20 - 31. Looking at bodybuilding forums, a normal range in healthy men (that is the range that counts) is indeed lower, 8 -13. This is just a piece of the puzzle ( I have more than a dozen of hormones low or high) but it is interesting to note that high prolactin lowers DHEA, and mine is of course low/very low. Somehow I think high prolactin has something to do with Adrenal Fatigue.

    Because I feel for you Ema , and there is no need to do weird things, I will tell you with details what I took for prolactin. It was a bodybuilding supplement called PowerFULL. It has a high quality extract of Mucuna and Safed Musli (basically aphrodisiacs but they do a host more of things).

    Remember, I have had my prolactin tested like 6 times or more in a range of two years. The only time it was inside the so called normal range was when I took this supplement.

    This is from 2011, when I was posting in bodybuilding/hormone forums, fighting with doctors to get regular testing and trying to correct my hormones thinking they were the only thing wrong. That didnt go well, but I am somehwat proud I managed to lower prolactin so much and boost free testosterone a lot also. If anyone is interested Nettle Root Extract boosted my free test 300%. Not much impact in symptoms I fear but I plan to try again also lowering my high estradiol and also back them I was better, now an improvement would be felt easily.

    My tested levels before taking PowerFULL were
    TAKEN THE 20 OF OCTOBER
    Prolactin (serum) 31,30 pg/ml 3,00-25,00 ng/ml

    After:

    TAKEN THE 21 OF NOVEMBER
    PROLACTIN SERUM- 5.13 ng/ml (2.60-18.1)
     
  18. Ema

    Ema Senior Member

    Messages:
    3,428
    Likes:
    3,818
    Midwest USA
    Thanks Beyond. I will check it out!
     
  19. Ema

    Ema Senior Member

    Messages:
    3,428
    Likes:
    3,818
    Midwest USA
    Looking at this supplement brings me back to a question I have about prolactin and the relationship to growth hormone.

    Reading on the Kruse forums, it seems like he is saying that a messed up circadian rhythm causes a lack of prolactin surge which leads to lowered growth hormone secretion. It seems like it is something about the prolactin surge that causes the growth hormone release and possibly the cortisol release later on in the early morning hours.

    So how exactly does that line up with the fact that bromocriptine lowers prolactin?

    I have high IGF1 which indicates at least the possibility of high growth hormone though I know the test is not perfect. But that makes more sense to me with high prolactin - that I am constantly secreting prolactin and thus have high growth hormone.

    How does a product such as this Powerfull lower prolactin and increase growth hormone? Those two seem like they are opposing.

    Ema
     
  20. Ema

    Ema Senior Member

    Messages:
    3,428
    Likes:
    3,818
    Midwest USA
    So my Cycloset trial is over. Too many side effects.

    I did lose a few pounds though so I'm clearly on the right track. Now just to find something that doesn't make me feel like dog doo.

    I'm going to take a week off and then try the next thing on my list - either selegeline or galantamine.

    Ema
     

See more popular forum discussions.

Share This Page