Hi, I have had unbelievalbe success with @Freddd's protocol versus more than a year and a half of taking it slow on others protocols. I am currently at 15 mg methylfolate (via methylpro) x2/day and Jarrow methylcobalamin 1.25 mg x2/day with quite a bit of success. I also support with ab12 and potassium gluconate. However, I notice that within 3-5 hours of taking the dose, I lose all the benefits. I am slower, thinking less clearly, less muscle strength, etc. I know the half-life of methylfolate is 6 hours but I am obviously taking an extremely large dose. Anyone have any idea why I have such a high need for folate? I take all supporting co-factors.