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High methylmalonic acid (MMA) test result

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Lucas, Jun 27, 2015.

  1. Lucas

    Lucas

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    Hello.

    I did the serum methylmalonic acid(MMA) test and it comes at 0,62 umol/L, Ref: 0,08 – 0,56.

    So, my MMA is out of range.

    Serum B12 comes at 997 pg/ml, without suplemention, and Homocysteine at 4,7 umol/L. Folic acid at 21,3 ng/ml.

    Is this a diagnosis of active b12 deficiency?

    I have Country Life, Methyl B12, 5000 mcg; Source Naturals, Dibencozide and methyl folate 400 mcg.

    I started at 1 tablet of methylb12 and half of dibencozide and fell sleepy, tired. Is this normal at the beginning?

    I had the MTHFR 677CT Hetero mutation.

    My symptoms are:

    - Fatigue

    - Brain fog

    - Depression

    - Low body temperature

    - Hair loss

    - Tremors on head at day, legs and hands when sleeping

    - Periodic movement limb disorder at sleeping

    - No - Refreshing sleep

    - Constipation

    - Joint pain and weakness on legs

    - Low stomach acid


    These symptoms correlate to b12 deficiency?


    How much methylb12 and adenob12 should I start to take?

    Thank you very much!!
     
  2. pogoman

    pogoman Senior Member

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    Your symptoms correlate with B12 deficiency altho they are shared with many other diseases and syndromes so you may have more than one issue.

    High MMA along with normal/high serum B12 levels may indicate a cellular B12 deficiency issue such as transcobalimin 2 deficiency.
    Hydroxocobalamin B12 orally or injections are listed as a treatment so that may be better for you if your have bad reactions to methyl types.
    Also, lithium orotate may help transfer serum B12 into cells.

    http://ghr.nlm.nih.gov/condition/transcobalamin-deficiency
    http://www.aafp.org/afp/2003/0301/p979.html
     
  3. Lucas

    Lucas

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    Thanks’.

    But since I don’t get anxious, insomnia, but fell tired and sleepy, this is a symptom of under methylation instead of over methylation?
     
  4. pogoman

    pogoman Senior Member

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    Have you talked to a doctor about your health issues?
    Its possible other things like the mitochondrial or endocrine systems etc are subpar and B12 is not working very well.
    But I would suggest talking to a doctor to see if other tests should be run, taking supplements blindly just gets expensive.
     

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