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High levels of isoprostanes causes low blood volume?

Discussion in 'General Treatment' started by Emootje, May 23, 2012.

  1. Emootje

    Emootje Senior Member

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    I'm hypovolemic and I tested very high on the urine isoprostane test. According to Dr. Bell these isoprostanes are the best candidates to cause low blood volume in CFS.
    Anyone an idea how to lower these isoprostanes?


    (9 -18min)

    emootje isoprostane.JPG
     
  2. Emootje

    Emootje Senior Member

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  3. globalpilot

    globalpilot Senior Member

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    Am I reading this correctly - your isoprostanes are 10x higher than the upper limit ?
    I have had mine measured 3x at laboratoire phillip in France. I have been able to cut the levels in half by doing:
    1. Rich's protocal
    2. liposomal glutathione
    3. vitamin E - tocotrienols and mixed tocopherols

    I'm still over the top of the range though so going to add ALA.
    You may already know this but isoprostane is a measure of oxidative damage to cell membranes (the fats) so you need fat soluble antioxidants for this.
     
    Emootje likes this.
  4. alex3619

    alex3619 Senior Member

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    Hi globalpilot, yes you need fat soluble antioxidants, but antioxidants work in networks. Fat soluble antioxidants pass the radical damage onto water soluble antixidants for elimination. These transfers go back and forth. So while fat soluble antioxidants are important, so are water soluble antioxidants. I think ALA is both fat and water soluble, so it has some possibly unique properties. Bye, Alex
     
  5. globalpilot

    globalpilot Senior Member

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    Thanks Alex, I understand and good point. I've had the water soluble (glutathione, pycnogenol, C, acai) on board for a while but was missing the fat soluble.
     
  6. Emootje

    Emootje Senior Member

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    Great - thanks for the helpful information.
    My test was done at Medivere and they indeed found isoprostane levels 10 times higher than the upper limit. I'm already on a broad spectrum anti-oxidant regime (sulforaphane, NAC, vitamin E complex, taurine, ascorbicacid, beta-carotene, ubiquinol) and I'm now going to add ALA, BHT and liposomal glutathione. The lab also recommended a diet low in arachidonic acid (vegan diet) so no more animal products for me...
     
  7. Emootje

    Emootje Senior Member

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  8. xchocoholic

    xchocoholic Senior Member

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    Thanks for posting this. Maybe this explains why my orthostatic hypotension went away one month
    after I stopped eating so much meat and added more veggies. I was on the paleo diet and eating 1/4 lb
    of meat per meal. In jan i switched to
    the wahls diet.

    I still have a bad case of pots tho. I get petite mals and sob if I'm up too long.

    Hmm, I'm low on elastace and high on lcfas so my metametrix fat levels were off. I'm experimenting
    with creon.
     
  9. Emootje

    Emootje Senior Member

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    CJB likes this.
  10. adreno

    adreno Homo neanderthalensis

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    Well, if isoprostanes are involved in all these diseases, it seems unlikely that they are the primary cause of OI.
     
  11. Emootje

    Emootje Senior Member

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    Good point Adreno!
    There must be something more, but what?
     
  12. adreno

    adreno Homo neanderthalensis

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    I wish I knew...
     
  13. August59

    August59 Daughters High School Graduation

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    Ecklonia Cava extract is a very good, strong fat soluble antioxidant. It alsso crosses the BBB and it also has a long half-life.
     
  14. Emootje

    Emootje Senior Member

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    Thanks August. I tried Ecklonia Cava and it made me feel slightly better :)
     

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