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High intake of vitamin B6 is linked to vitreous detachment

Discussion in 'Other Health News and Research' started by pattismith, Feb 5, 2018.

  1. pattismith

    pattismith Senior Member

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    I suddenly experienced posterior vitreous detachment for some weeks/months ( floaters) and I took high dose of B6, and I am premonopausal myopic woman, so I do some quick researches and found it....I match perfectly with all the risk factors...

    Risk factors for posterior vitreous detachment: a case-control study.


    Abstract
    PURPOSE:

    To identify possible risk factors for the development of posterior vitreous detachment (PVD).

    DESIGN:
    Retrospective case-control study.

    METHODS:
    A total of 138 cases with PVD and 114 age-matched controls were accrued from two different sites. Demographic, medical, ocular, and lifestyle data were obtained through chart review, questionnaires, and clinical examination. A 108-item semiquantitative food frequency questionnaire was also used to estimate macro- and micronutrient intake. Univariate and multivariate regression analyses were employed to identify variables significantly associated with the main outcome measure of PVD. Subgroup analysis of gender-specific variables was performed.

    RESULTS:
    Among all patients, multivariate regression analysis demonstrated female gender (odds ratio [OR] = 2.01, P = .016), myopic refraction (OR = 4.32, P < .0005), and higher intake of vitamin B6 (OR = 2.61, P = .001) to be associated with PVD after controlling for age.

    In the subgroup analysis of women, menopause
    (OR = 18.2, P < .0005), myopic refraction (OR = 3.42, P = .01), and higher intake of vitamin B6 (OR = 3.92, P = .005) were associated with PVD. Specifically, there was a significant association between vitamin B6 and PVD amongst premenopausal women but not amongst postmenopausal women.

    CONCLUSIONS:
    An association between PVD and menopause has not been documented previously.

    We suspect that high estrogen levels seen in premenopausal women may be protective against PVD and that hormonal changes associated with menopause may lead to changes in the vitreous, predisposing to PVD. Higher levels of intake of vitamin B6 were also associated with the development of PVD in premenopausal women possibly through an anti-estrogen effect.

    These findings should be investigated further with prospective studies.
     
    Last edited: Feb 6, 2018
    andyguitar and Sancar like this.
  2. Learner1

    Learner1 Professional Patient

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    ??? They estimated nutrient intake based on a list of foods people ate. What if the people ate foods not on the list? What if their portion sizes varied? What if their genetics or environmental exposures made them use up more or less of various nutrients? What if some subjects weighed 100lbs and some weighed 300lbs?

    Did anyone measure the levels of nutrients in their blood or urine?

    There are a lot of scare tactics warning people from taking supplements, using supposedly "evidence based" studies that are bad science.

    Some of us actually NEED high doses of B6... It's used in the production of heme and sphingolipids, as well as at several points in the process of methylation and glutathione production.

    It is important to know if we have deficiencies or imbalances before taking random supplements. Additionally, they don't stand on their own, they typically work with other cofactors in biochemical processes.

    Customizing nutrient intake based on individual needs can be very powerful.
     
    PatJ and pattismith like this.
  3. drob31

    drob31 Senior Member

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    b6 is also important for lowering prolactin (for those with high levels) and thus increasing dopamine (for those with low levels), via assisting with converion of tyrosine to dopamine.
     
  4. pattismith

    pattismith Senior Member

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    I don't know if they calculated B6 intake correctly, but I was amazed that I match perfectly with every risk factors of this paper!;)

    I may wait until menopause to go back to B6...
     
    andyguitar likes this.
  5. Learner1

    Learner1 Professional Patient

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    I'm taking 350mg P5P daily and am finally not testing as severely deficient. I know its a lot, but my body is using it for all the functions described below from Revolution Health.

    Are you sure you or the subjects of the study aren't missing cofactors causing bottlenecks in pathways that can lead to symptoms and disease?

     
    pamojja likes this.

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