Hi everyone, I've just gotten results back from a methylation blood panel done after I was just hospitalized. Long story short, I was dealing with neurological symptoms similar to Myasthenia Gravis, but once I was hospitalized (and taken off my supplements) I got better. After being discharged I discovered I had 5x upper limit of B6 in my plasma. Which was upsetting but surprising, as I had a urine amino acids test done just 2 months ago that showed no B6 metabolites. I was told to try 100mg of P5P, and 2 months later I was in the hospital. What's even more peculiar is that I'm looking at my methylation report, and something is strange: https://drive.google.com/file/d/0B2aK7-_YzJAtZ0NRWDFiakpDV00/view?usp=sharing My Genetic Genie: https://drive.google.com/file/d/0B2aK7-_YzJAtcmRhYjN1dndzcjQ/view?usp=sharing If B6 is a cofactor for CBS, I should expect to have lowish homocystine if I had just been hospitalized with a high B6 level, right? I do have BHMT mutations (+/+) I've been trying to get methylation working for me for forever. I nearly always read about people either struggling with too fast a CBS or a CBS that works normally. I know nothing about CBS that works too slowly, and I wonder if that is something I am dealing with here? I have quite frankly terrible numbers as far as methylation goes. I found 50mg of SAMe to be helpful right after the hospitalization, and no wonder. My SAM/SAH ratio is quite bad, and with this high homocystine there should be no reason for it not to be bad. 2 ideas pop up here: 1) looking at Dr. Ben's Pathway Planner poster, I see that Serine and Cystine are needed for Hcy to become cystathionine. Luckily, I have a plasma amino acids test with results coming very soon. I can see if I'm lacking in either amino acid. But do I have a problem elsewhere on the transulferation pathway? 2) MTR is supposed to pull homocystine into the methylation cycle. This is the cobalamin dependant portion from what I understand from the Planner. I did have a low methylmalonic acid (B12) level at the hospital. Perhaps there is an issue to address there? The prospect of a transulferation pathway problem is daunting. I don't know what to look for. I have a great methylation report from MTHFRSupport that will show me mutations for many more genes. I see I have 2 mutations (+/+) mutations of the CTH gene (there are 7 CTH genes on this report, the rest are (-/-) ) Anyone run into this before, or dealt with it themselves? Thanks, and please let me know if the links work for you!!!