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High homocystine, but why? Methylation report inside

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Tom_Nightingale, Nov 11, 2015.

  1. Tom_Nightingale

    Tom_Nightingale

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    Hi everyone,

    I've just gotten results back from a methylation blood panel done after I was just hospitalized. :( Long story short, I was dealing with neurological symptoms similar to Myasthenia Gravis, but once I was hospitalized (and taken off my supplements) I got better. After being discharged I discovered I had 5x upper limit of B6 in my plasma. Which was upsetting but surprising, as I had a urine amino acids test done just 2 months ago that showed no B6 metabolites. I was told to try 100mg of P5P, and 2 months later I was in the hospital.

    What's even more peculiar is that I'm looking at my methylation report, and something is strange: https://drive.google.com/file/d/0B2aK7-_YzJAtZ0NRWDFiakpDV00/view?usp=sharing

    My Genetic Genie: https://drive.google.com/file/d/0B2aK7-_YzJAtcmRhYjN1dndzcjQ/view?usp=sharing

    If B6 is a cofactor for CBS, I should expect to have lowish homocystine if I had just been hospitalized with a high B6 level, right? I do have BHMT mutations (+/+)

    I've been trying to get methylation working for me for forever. I nearly always read about people either struggling with too fast a CBS or a CBS that works normally. I know nothing about CBS that works too slowly, and I wonder if that is something I am dealing with here?

    I have quite frankly terrible numbers as far as methylation goes. I found 50mg of SAMe to be helpful right after the hospitalization, and no wonder. My SAM/SAH ratio is quite bad, and with this high homocystine there should be no reason for it not to be bad.

    2 ideas pop up here: 1) looking at Dr. Ben's Pathway Planner poster, I see that Serine and Cystine are needed for Hcy to become cystathionine. Luckily, I have a plasma amino acids test with results coming very soon. I can see if I'm lacking in either amino acid. But do I have a problem elsewhere on the transulferation pathway? 2) MTR is supposed to pull homocystine into the methylation cycle. This is the cobalamin dependant portion from what I understand from the Planner. I did have a low methylmalonic acid (B12) level at the hospital. Perhaps there is an issue to address there?

    The prospect of a transulferation pathway problem is daunting. I don't know what to look for. I have a great methylation report from MTHFRSupport that will show me mutations for many more genes. I see I have 2 mutations (+/+) mutations of the CTH gene (there are 7 CTH genes on this report, the rest are (-/-) )

    Anyone run into this before, or dealt with it themselves?

    Thanks, and please let me know if the links work for you!!!
     
  2. helen1

    helen1 Senior Member

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    Do you think the B6 supplementation caused your neurological problems?
     
  3. Tom_Nightingale

    Tom_Nightingale

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    I do :( I took B6 again after I was discharged, because I wasn't told about the high level. That very day I was able to get a printout of alllll the labs they did, and there it was a high B6. I was feeling quite worse that day, terrible I found out just hours too late before I took another dose. In talking with others with B6 toxicity (there is a large group on Facebook) it seems as if everyone's experience is that doctors have no training in how to respond to high B6. Pretty much on our own
     
  4. PeterPositive

    PeterPositive Senior Member

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    There is a risk in taking a high dose B6 supplement especially if you're already low on other components of the B family, such as B12 etc... They all work together, and the lack of one can block the action of others or increase the risk of potential side effects, etc...

    Your homocysteine, overall, isn't that bad, only slightly elevated but the methylation panel doesn't look good indeed. Have you tested your folate and B12 status perchance? (E.g. methylmalonic acid etc...)

    Also, as a side note, all of the methylation panel results I have ever seen all look the same, just like yours :)
    The same pattern of low SAM, GSH and high SAH and adenosine recurs like Xmas on the 25th of December ... It's still not clear to me if this cause or effect of chronic illness...
     
  5. Valentijn

    Valentijn Senior Member

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    The fears about "fast" CBS SNPs are almost completely baseless. CBS C699T is an up-regulation, but it's a very mild and beneficial one.

    The pathogenic mutations on the CBS gene are all serious down-regulations. I've got a list of the ones tested by 23andME, which are shown to have an impact in the available published research, at http://forums.phoenixrising.me/index.php?threads/interesting-cbs-variations.24492/
     
    PeterPositive likes this.
  6. Aerose91

    Aerose91 Senior Member

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    What does a low level of methylmalonic acid indicate?
     
  7. PeterPositive

    PeterPositive Senior Member

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    It usually means that vitamin B12 status is fine.
     
  8. Aerose91

    Aerose91 Senior Member

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    That seems odd to me. Something being low which is related to b absorprion means that b12 levels are normal? What does normal methylmalonic acid mean then?
     
  9. PeterPositive

    PeterPositive Senior Member

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    Only elevated levels of methylmalonic acid are considered clinically relevant.
    See here, for instance --> https://labtestsonline.org/understanding/analytes/mma/tab/test/
     
    Valentijn likes this.

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