A New Decade of ME Research: The 11th Invest in ME International ME Conference 2016
Mark Berry presents the first in a series of articles on the 11th Invest in ME International ME Conference in London ...
Discuss the article on the Forums.

High Glutamate Keeps Cysteine Levels Low?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Valentijn, Oct 20, 2011.

  1. Valentijn

    Valentijn The Diabolic Logic

    Messages:
    14,048
    Likes:
    43,584
    Another potential vicious cycle:

    http://www.ncbi.nlm.nih.gov/pubmed/8441757

    Glutamate gets high, inhibits cystine transport, less cysteine available for glutathione, more glutamate hanging around with nowhere to go ...

    I'm starting to see ME/CFS as a compelling argument for the theory of Intelligent Design :p
     
    aaron_c likes this.
  2. aaron_c

    aaron_c Senior Member

    Messages:
    618
    Likes:
    953
    Ancient thread, I know...but this may have answered a question I have.

    I just started taking NAC because I think I might be deficient in cysteine. It has helped to some degree with memory/focus and sleep issues. Unfortunately, those issues seem to benefit from a higher dose of NAC than my guts can take. I tried to fix this by adding glutamine, which sort of fixed the diarrhea. Unfortunately, the NAC appears to have become less helpful around the same time I added more glutamine. Perhaps this is because enough of the glutamine becomes glutamate, and that is interfering with cysteine transport?
     
  3. Gondwanaland

    Gondwanaland Senior Member

    Messages:
    4,435
    Likes:
    3,390
    No matter what variables, I frequently read testimonials saying that NAC benefits fade out pretty quickly. So it is in my personal experience as well.
     
    aaron_c likes this.
  4. aaron_c

    aaron_c Senior Member

    Messages:
    618
    Likes:
    953
    What benefits are you referring to @Gondwanaland ? I ask partly because I haven't really read about people taking NAC to help with concentration.
     
  5. Valentijn

    Valentijn The Diabolic Logic

    Messages:
    14,048
    Likes:
    43,584
    It's worked consistently for me over several years now.
     
    aaron_c likes this.
  6. Gondwanaland

    Gondwanaland Senior Member

    Messages:
    4,435
    Likes:
    3,390
    Against inflammation (pain). But it gave me massive BP drops in BP about 2h after lunch.

    Also I read that it raises glutathione (good) but glutathione in its turn can convert to glutamate (bad).
    I felt its good effects :thumbsup:, but couldn't bear the sides :thumbdown:
     
    aaron_c likes this.
  7. Valentijn

    Valentijn The Diabolic Logic

    Messages:
    14,048
    Likes:
    43,584
    This wouldn't really qualify as bad (if it actually can happen) since it would be releasing glutamate that was already on the loose before it combined to form glutathione. It wouldn't result in any net increase in glutamate, except (theoretically) if supplementing glutathione instead of NAC.
     
    Gondwanaland and aaron_c like this.
  8. aaron_c

    aaron_c Senior Member

    Messages:
    618
    Likes:
    953
    Ah...Lucky for me I don't have major BP problems.
     

See more popular forum discussions.

Share This Page