I have been doing a lot of research about lyme and niacinamide in doses of 3g per day has been shown to be extremely effective for treatment. Many people are raving about it and I would like to try it. I am concerned about how this relates to methylation because I know niacin can possibly mop up methyl groups. How much niacinamide does it to take to really effect the methylation cycle? Would I need to take additional methyl donors such as TMG to compensate for the niacinamide?