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High dose ALA seems to help my HPA-axis related blood sugar issue

Discussion in 'Adrenal Dysfunction' started by drob31, Sep 14, 2017.

  1. drob31

    drob31 Senior Member

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    ALA seems to have a huge affect on being able to eat without crashing / being fatigued from it. It seems the ALA is forcing the cells to use glucose properly.

    I'm taking 600mg, 3 times a day with a meal.
     
    ryan31337, Tunguska, ebethc and 2 others like this.
  2. alex3619

    alex3619 Senior Member

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    Alpha linolenic acid, alpha lipoic acid, or alanine? The first time you use an acronym it would be good to define it. My guess is lipoic acid as it helps conversion of pyruvate.
     
  3. drob31

    drob31 Senior Member

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    Sorry, Alpha Lipoic Acid. It also contains biotin. Also ALA depletes thiamine, so I'm taking benfotiamine with it to refill it.
     
  4. alex3619

    alex3619 Senior Member

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    I sometimes get post prandial crashes. While I have used ALA before I have not tried lipoic at those doses. It might be something I will try.

    PS Taking my own advice, and so nobody has to look it up, post prandial means after food.

    PPS I have had a small benefit from ALA, biotin and B1 in the past.
     
  5. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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    Biotin was started/increased just before my weird crash last year from which I still haven't recovered, but it could just be a coincidence.

    I have now also stopped alpha lipoic acid as that appears to have adverse effects on some people. I was taking it combined with acetyl-l-carnitine for several years.

    I'm taking acetyl-l-carnitine on its own now - so far so good, but haven't been doing it for long, and I am acutely aware of the different effects of various things on men and women.
     
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  6. ljimbo423

    ljimbo423 Senior Member

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    Another thing that ALA does is to boost glutathione, which many people with cfs are low in. The increase in glutathione can cause significant detox symptoms in some people.

    If you have been taking that dose for more than a few days though, you probably won't have any problems with the detox symptoms. I take 475mg ALA every day.

    Jim
     
  7. dannybex

    dannybex Senior Member

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  8. Isaiah 58:11

    Isaiah 58:11

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    A Sun-Scorched Land
    To be fair, I haven't had lab work done specifically as before and after, but taking actual-l carnitine seems to be the *only* way to get my body processing fats and seems (symptomatically) to help with insulin and glucose regulation. Plus the energy boost is incredible!

    I do actually have a demonstrable carnitine deficiency though (my acyl ratio is screwy) and am supposed to take 2 grams per day. I stopped for a while because carnitine increases testosterone receptors and I didn't want to make my hormonal issues worse, but then I ended up on Metformin which was so harmful to my mitochondria that I had ALS-type symptoms. Quitting the Metformin and restarting the carnitine has been one of the best things I have ever done for myself; I feel so much better.

    I wonder if carnitine is this awesome for everyone... Am I the only one with a demonstrable deficiency or is that "normal"? Have you had any tests done to check your levels?

    Edited to add: Since you have taken both carnitine and ALA, I will mention that ALA made me feel terrible (sulfur issues). I took it on doctor's orders but stopped after cutting my foot and getting tetanus vaccine and the other that comes with it (can't remember). Those basically killed what was left of my memory and intelligence at that point. After learning ALA was a chelator I figured I had just directly moved all the mercury from the injections into my brain and quit immediately. I want to try Cutler's protocol, but haven't been able to purchase the book. I did notice a cognitive benefit from Nutramedix's Sealantro which shouldn't be possible based on my understanding of Cutler. Maybe done Cutler's way I would see a benefit from ALA?
     
    Last edited: Sep 14, 2017
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  9. ebethc

    ebethc Senior Member

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    I've been taking ALA lately and it's really been great for me.... I could have sworn that i tried it a few years ago and got nothing from it, which just goes to show that timing if everything... Nothing helps until I've had a lot of rest!

    I've been doing 300mg 3-4x per day, and I'd like to bump it up to 1500 - 2400 mg per day.. I just found this study of high dose ALA in MS patients ..This is interesting (high dose ALA in MS patients) b/c it notes changes in MMP-9, which is one of the tests recommended by Shoemaker! I don't know what it means, but I found it very interesting.. The dosages tested were 600 mg, 1200 mg and 2400 mg per day... The higher doses got results.
    https://www.ncbi.nlm.nih.gov/pubmed/15794388
     
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  10. drob31

    drob31 Senior Member

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    MMP-9 has to do with "leaky blood brain barrier."

    From my last blood test:

    MMP-9 (Matrix metalloprot.-9)

    Methylmalonic Acid, Serum:
    Reference Range: 0-378 nmol/L

    176
    NORMAL


    I am taking about 2400 mg a day now, about 600 mg with each meal. I have no idea what mechanism is at work, however. It seemed like for a day or so, I was getting bad gas with the ALA. Now, even at the same dose, it seems to be going away.

    Killing bad gut microbes?
     
  11. drob31

    drob31 Senior Member

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  12. ebethc

    ebethc Senior Member

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    Last edited: Sep 25, 2017
  13. drob31

    drob31 Senior Member

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    What do you recommend for the range?
     
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  14. ebethc

    ebethc Senior Member

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    Last edited: Sep 25, 2017
  15. drob31

    drob31 Senior Member

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    Yeah I'm sure it's set up to benefit insurance companies somehow.

    In any case my health insurance is pretty sub par, so what I do is pay an "integrative doctor" out of pocket, then tell him what lab tests I want, and then run the labs through insurance, because a doctor covered under insurance would never do it. Labcorp said my last batch of labs cost 7 grand, and I think they charged me like 12 dollars.
     
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  16. ebethc

    ebethc Senior Member

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    Last edited: Sep 25, 2017
  17. drob31

    drob31 Senior Member

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    Yeah it's probably like a few hundred dollars worth of tests, realistically. Maybe @Hip would know why it's so expensive.
     
  18. Hip

    Hip Senior Member

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    I don't know how lab tests are priced, or whether they are a good value for money or not. Drug prices in the US are a bit higher than they are in Europe, so possibly the same markup might apply to lab tests.
     
  19. drob31

    drob31 Senior Member

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    ALA seems to be effective for helping me utilize carbs.

    also there is some synergy with baking soda, but I have no idea what.
     

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