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High dose Acyclovir

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by m1she11e, Jun 4, 2013.

  1. SOC

    SOC Moderator and Senior Member

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    jimells, Valtrex is quite safe (as antivirals go) and has a relatively low side effect profile. It has been used as a long-term prophylactic medication for genital herpes for 10 years or more, so there's a lot of experience with long-term Valtrex use without serious side effects. This is why some docs are willing to prescribe it for chronic HHV-6 even though it's not particularly effective for that.

    Valcyte is much more effective for chronic HHV-6, but has much more serious potential side effects so the patient needs to be carefully monitored. Many docs are afraid to use it for that reason. And it's absurdly expensive...... speaking of absurdly expensive, are you sure you aren't taking Valcyte? Valtrex is not ordinarily that expensive, I think. :confused: Relatively speaking, of course. Antivirals aren't cheap in any case.

    Daughter and I have been taking Valtrex at a high dose for a couple of years now to keep HHV-6 and EBV suppressed once we got them back into latency with Valcyte. Neither of us has had any side effects from Valtrex. :)
    jimells and heapsreal like this.
  2. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Important point is that if valtrex or famvir dont lower cmv and hhv6 effectively but seem more effective at keeping these viruses down once something like valcyte lowers the dam virus, supposedly? ? But they have helped many famvir/valtrex? ?
  3. SOC

    SOC Moderator and Senior Member

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    Dr Lerner was talking well above my knowledge level on this topic, but I think it has something to do with the stage or position where the antiviral cleaves (or obstructs?) the virus during replication...? o_O So while Valtrex works well on active HSV and EBV infections, it's not so good for active HHV-6 or CMV. However, it is helpful to keep all latent herpes viruses from reactivating. Or so I understood it. I could have it entirely wrong. :ill:

    I don't know where Famvir fits into this picture.
    heapsreal likes this.
  4. Ema

    Ema Senior Member

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    My liver enzymes have recently started climbing up again...I was wondering if it was the Valtrex possibly. They aren't awful but is this something you've ever seen with Valtrex in your experience, SOC?

    Valtrex is ridiculously expensive and Valcyte is absurdly expensive. I think the 30 day supply of generic Valtrex at 1g 4x/day was around $1000 at CVS without insurance. The generic Valcyte was around $5000 if I remember correctly for a 30 day supply of 900 mg/day. Either way is unaffordable without insurance for most unfortunately.

    Ema
  5. SOC

    SOC Moderator and Senior Member

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    We haven't experienced an increase in liver enzymes with Valtrex, but I wouldn't be surprised. It's processed by the liver (as are many meds) so the extra burden could cause some problems. We did get mild increases in liver enzymes with Valcyte, but they went back to normal after we were done with Valcyte treatment.

    We do take some supplements to support the liver, so that might be why we haven't had much problem. When we were taking Valcyte, we also took milk thistle. Now we take this product, which has milk thistle, but less than we were taking with Valcyte.

    :rofl: (Better to laugh than cry) So true! I think I'm blocking out how horrendously expensive Valcyte and Valtrex treatment for 2 people has been, even with insurance. Maybe I should get some CBT for my false economic beliefs. :rolleyes:
    jimells likes this.
  6. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Do u take things to support your liver, probably a silly questions as u probably take fist fulls of supps like the rest of us?? the price of antivirals is why i started buying them online. for me the cost of famvir was $200 a month at the dose i was taking , online it was costing $75. ALso famvir was cheaper then valtrex.
  7. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    yes, thats basically what i have found researching this stuff. valtrex and famvir are used to prevent cmv infections in organ transplant patients where it seems that active infections are treated with valcyte or other antivirals more specific to the virus.
    Famvir is something that i think needs to be looked into further as its possibly effective against these viruses when active, maybe not as strong as valcyte. Its all chinese whispers but its said that famvir was only marketed for hsv and shingles and wasnt pushed to be marketed for other viruses as they didnt think there was a need for it?? There is research saying it works in lowering viral load in hepatitis, so maybe has a broader range of action then we know off?? I think it probably falls between valtrex and valcyte and is a more affordable alternative to valcyte??
    jeffrez and SOC like this.
  8. Ema

    Ema Senior Member

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    My liver is so supported that the only other thing I can think of would be to buy it a bra. :)

    Ema
  9. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    lol:thumbsup:
  10. SOC

    SOC Moderator and Senior Member

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    :rofl: :rofl: Not sure I wanted that image right before bed -- some crazy dreams in my future. ;)
    heapsreal likes this.
  11. jimells

    jimells Senior Member

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    Thanks for the explanation. I wondered why the HHV6 Foundation website didn't list Valtrex. I haven't seen anything about possible liver damage, but I was warned to drink lots of water to protect my kidneys. I've been drinking 2 liters a day for years to help with the POTS - I guess that should be enough.
  12. SOC

    SOC Moderator and Senior Member

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    Oops! :redface: Valcyte/Valtrex darned names are so confusing. I think the liver issue is for Valcyte. With Valtrex, you need to drink lots of water (as you are doing) to prevent kidney stones.
  13. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    i have read that dr lerner will use famvir if one is prone to kidney stones as it doesnt have that side effect.
    jeffrez likes this.
  14. WillowJ

    WillowJ Senior Member

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    ouch. depending on your insurance, could be unaffordable even with insurance.
    Jarod likes this.
  15. 1WearyChick

    1WearyChick

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    m1she11e

    Is Dantini your current doctor?

    He was one of mine several years ago.
  16. morinos

    morinos

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    May be you want to try russian antivir - "panavir". Not sure if its selling somewhere outside Russia, but may be u can find shipping. Its probably number 1 popular antivir(mostly anti herpes) in Russia. It was tested good for CMV, EBV. But i didint find information about HHV-6.
    I didnt not use it for myself, because my PCR for CMV and HHV 6 is negative. Anti EBV NA IgG 129. So my doc said i dont need antivir.
    If u will try to use it - u need only 5 injections. Other forms - not for us. It cost around 130$ for 5 injections in Russia.
  17. maryb

    maryb iherb code TAK122

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    Don't think its available outside of russia, is it true you have to be invited to russia in order to get a visa? Just curious not thinking of travelling..........
  18. m1she11e

    m1she11e Senior Member

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    No, I only had one phone consultation with him and he was the first to prefer Famvir to Valcyte.
  19. anniekim

    anniekim Senior Member

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    Have been on 4 x800 mg acyclovir for four months now. Sadly no benefit as of yet, still bedridden
  20. energyoverload

    energyoverload

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    Mishelle,

    How are you doing at the moment on the high dose Aciclovir and more positive changes to report?

    Thanks

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