I dont have much time but I thought this was important to post. I have posted many times through out the virus threads if you want to find more details. In the last 4 or 5 months I have been much better. (Long post in General treatments thread) I wasnt sure if anti virals really helped me a whole lot. I had been on Famvir at 500mg, 3 times a day for about 2 years. I never had die off or felt better or worse. My doc switched me to Acycovir 800mg, 4 times a day. It was important to him that I take 2 at a time and with meals. He said he was getting better results than Valcyte with this dosing. Also, no extreme side effects. I thought Acyclovir was like the PEZ candy of anti virals so I didnt really think it was doing anything either. A few months ago I lost my insurance and this high dose of Acyclovir isnt cheap. I slowly took less and less and totally ran out about a month ago. I did however have some Famvir 500 mg. I was feeling a little sore throat coming on and faint symptoms that had slowly fallen away. I took the Famvir 500 mg, 3 times a day for the last month. It was useless against my symptoms. Finally it all unraveled. I suddenly woke with that crushing fatigue that I havent had since a few months on the Acyclovir. (Other things were helping too so until this little experiment I doubted Acyclovir was even one of the thing that was really helping) Famvir did NOTHING for the symptoms and I went from working out daily to barely being able to climb the stairs. I spent 2 days in bed. This was an unpleasant walk down memory lane for me!!! The only thing that had changed was that I was out of Acyclovir and had been for about a month. Finally I used money I did not have and got my Acyclovir. Im taking the high dose I mentioned above again and within only a few days my bone crushing fatigue has lifted. I still am climbing out of the hole but I feel upward momentum for certain. My point here....If you can get Acyclovir at 800 mg, taking 2, 2 times a day I would give it a try. Yes, that is 1,600mg, two times a day with food. Im not sure why it is helping but I could not tolerate Valcyte. Famvir was obviously doing nothing. I guess that Acyclovir was really helping me after all. Its the cheapest, easiest to get and has the fewest side effects. This is a whopping dose though. I can only imagine what my pharmacist things when he hands me that much Herpes medicine!!! It has been about 5 months that I have been doing so well. I forgot what that fatigue that you can barely sit upright feels like. Usually I get scared that Im crashing to the depths of sick hell when I feel like that. For whatever reason I didnt feel it was here to stay. I felt positive it would pass and it is. Hope this helps someone!!