@ahmo- I have been increasing mine as well and I am getting histamine issues too! But I don't notice them until I go to bed and I can't sleep. If I take a MB12, it would give me energy. This last two days I have been trying to spread out the MB12 so that I take it with the folate. Let me know how it goes. I am up to 7.2 in three doses. @WDTI Before I started to increase from 2.4 to 7.2 of folate, I had a really high tolerance for anything. I have business that involves at least 1,000 families and their kids, and let me tell you each day I have "unique" highly emotional problems to solve with compassion and consideration. However, since I have increased my does, I have no tolerance at all. I would describe it as being a witch with a "B". I went through something similar when I first started this protocal several years ago. i'm just hoping it goes away soon before my family, friends and coworkers vote me off the island.