The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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High Dopamine / Methylation

Discussion in 'General Treatment' started by Hope78, Jul 19, 2016.

  1. Hope78

    Hope78 Senior Member


    In 2014 I was tested for neurotransmitters and was very high in dopamine, normal in norepinephrine, normal to high in serotonine and low in epinephrine.

    I now repeated the test with nearly the same result: still too much dopa and low in epinephrine.

    High dopa is probably due to slow versions of MAO A+B and COMT. Low epinephrine is about being short in methyl groups.

    The dilemma: as soon as I try to boost my methylation (SAMe, TMG, methylB12 and so on) my dopamine rises and as it's already elevated I feel agitated with anxiety and very vidid nightmares. A big no because insomnia is one of my main problems.

    So any suggestions how I can improve my methylation without further rising dopamine?

    Are there any dopamine lowering supplements I am not aware of?

    Thank you!
  2. JaimeS

    JaimeS Senior Member

    Mid-Ohio Valley, United States
    SAMe would elevate serotonin, and that may well contribute to feelings of anxiety and crazy dreams. A lot of the high serotonin and high dopamine symptoms are similar.

    If you are 'very high' in dopamine, you might want to talk to a physician you trust about dopamine-blockers.

    If you don't have a physician you can trust, you might want to check out Bacopa monierii -- here is a list of research on its effect on dopamine and on serotonin.

    I wouldn't aim for methylation right away... is there a reason that's the type of treatment you're going for?

    South likes this.

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