1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Nitric oxide and its possible implication in ME/CFS (Part 2 of 2)
Andrew Gladman explores the current and historic hypotheses relating to nitric oxide problems in ME/CFS. This second article in a 2-Part series puts nitric oxide under the microscope and explores what it is, what it does and why it is so frequently discussed in the world of ME/CFS....
Discuss the article on the Forums.

High Citrulline Level

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Waverunner, Aug 5, 2011.

  1. Waverunner

    Waverunner Senior Member


    just received some new results.

    Some weeks before I got these:

    GSH cellular (CD3): high end of scale (norm >650, me: 1500)
    B12: normal/high
    Holo-transcobalamin: high end of scale (norm >35, me: 90)
    sIgA saliva: high end of scale
    sIgA intestine: nearly non existent
    total IgE: high end of scale


    KPU: negative (4.7 g/dl while norm is smaller 13)
    Methylmalonic acid: normal/low (0.69 mg/g Creatinine while norm is smaller 2)

    Citrulline: high (187.2 mol/g Creatinine while norm is smaller 100)

    It is said that citrulline is high during l-arginine or l-glutamine supplementation but I take no supplements at all. Moreover citrulline can be reduced through B12 supplementation. When arginine gets transformed to citrulline the byproduct NO is produced. Does anyone have any ideas on what tests I should do in order to find out the cause of high citrulline? Is it worth to find out why citrulline is high?
  2. BiancaS


    High citruline usually means you have nitrostative stress, which needs to be treated. Typically, this is treated with B12 supplementation, but you seem to be OK there. Pall describes quite well how nitrostative stress is treated. Maybe somebody can give you feedback as to what needs to be checked to find the cause.
  3. richvank

    richvank Senior Member

    Hi, waverunner.

    Low magnesium can cause high citrulline, because it's needed by the enzyme in the urea cycle that uses citrulline.

  4. Waverunner

    Waverunner Senior Member

    Thanks a lot for your answers. I remember that I had problems with cramps before and on the day the test was done so it really could have been low magnesium, Rich. I take magneisum and B12 and a multi mineral with no iron now.

See more popular forum discussions.

Share This Page