Hi, I'm really suffering with insomnia, depression, anxiety and chronic fatigue at the moment, all of my symptoms are psychological/fatigue related. I'm seeing a few doctors at the moment but so far no one has really been able to help. Often when I try to take basic supplements like B12, I feel overstimulated and it makes my anxiety/insomnia much worse. I've used P5P on and off for a while, sometimes it helps me to relax other times I feel like it's adding to the over stimulation. Some of the problems I have: - High ammonia - High oxalates - Homocysteine is 6.1 - Low glutathione - Neurotransmitters are high glutamate, low gaba/serotonin - SIBO (streptococcus overgrowth, citrobacter), candida - Thyroid - high reverse T3 - High cortisol - B2, B6, Biotin deficiencies - Mineral deficiencies (at least magnesium/selenium) For CBS - I have CBS A360A+/+, but unaffected by - CBS C699T Tests that I've had done can be viewed here: https://drive.google.com/drive/folders/0B20YfaNvgCdnLVhyZ1k5dndWSDg I've tried to treat the SIBO/candida with probiotics and antifungals for 6 months but seen no improvement and I'm now at the point where side effects from antifungals are intolerable and have stopped using them. I've started to look into the ammonia issue, and have noticed when I used activated charcoal I felt much better, but am afraid to use it frequently. I've tried Ornithine, it gives me some relief for about an hour but then I get anxiety/anxious. I don't have constipation/bloating or anything like that, even when using the charcoal it passes through but takes 24 hours. I'm taking Pure encapsulations gi fortify, Lactobacillus GG, saccharomyces boulardii and a small dose of Bifidobacterium lactis and Lactobacillus rhamnosus. I suspect my body is toxic, I have cold hands/feet, my body generally feels cold all the time, my tongue is very white, my nails are very white. I'm kind of lost as to whether I should be focusing on reducing ammonia with things like Yucca, or somehow try to treat the gut (without antifungals) instead? I've ordered a methylation profile panel but don't have the results yet. My diet is steamed vegetables, salmon, salads, some chicken. It was previously high in beef/lamb etc, but have stopped that recently (didn't notice much improvement though). I don't think I have parasites but again stool test was only x1, so not 100% certain. I sometimes see relief with antifungals, but it's usually short term. Appreciate any help..