The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
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HHV-6A Found in 22% of ME/CFS Patients' PBMCs, but in Only 4% of Healthy Controls'

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by Hip, Dec 7, 2015.

  1. Hip

    Hip Senior Member

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    In 2012, the International Committee on Taxonomy of Viruses classified HHV-6A and HHV-6B as separate viruses (prior to that they were considered subtypes of HHV-6). Ref: 1

    However, even though HHV-6A is a distinct and separate virus, since nearly all HHV-6 tests cannot distinguish between HHV-6A and HHV-6B, and since HHV-6 is found in nearly everybody (so nearly all HHV-6 tests are going to come back positive for having the virus), by standard labs tests, it is hard to know whether you might have HHV-6A or not.

    According to the HHV-6 Foundation, testing laboratories that can detect HHV-6A include:

    • Viracor-IBT Laboratories — HHV-6 Quantitative Real-time PCR

    • Focus Diagnostics

    • Wisconsin Viral Research, who have now become Coppe Labs.



    HHV-6A seems to be a significant virus for ME/CFS:

    One study of 36 ME/CFS patients and 24 healthy controls found HHV-6A in the peripheral blood mononuclear cells (PBMC) of 22% of ME/CFS patients, but only in 4% of healthy controls.

    This study of 13 ME/CFS patients and 13 healthy controls found HHV-6A in the PBMCs of 31% of patients, HHV-6B in the PBMCs of 23% of patients, and no HHV-6A nor HHV-6B found in the PBMCs of healthy controls.

    However, although the above studies found little to no HHV-6A or HHV-6B in the PBMCs of healthy controls, somewhat confusingly, this study of healthy individuals found HHV-6A in 16% of subjects' PBMCs, and HHV-6B in 98% of subjects' PBMCs.



     
    Last edited: Dec 7, 2015
  2. Hip

    Hip Senior Member

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    One additional point:

    Almost all of us will have picked up HHV-6B by the age of 2. This means that HHV-6B is very unlikely to be a triggering virus for ME/CFS. This is because most people come down with ME/CFS later in life, in their teens, 20s, 30s and 40s typically, long after we have caught HHV-6B as an infant.

    By contrast, HHV-6A when caught is picked up later in life. So this means that HHV-6A might be a candidate for a triggering virus of ME/CFS. By a triggering virus, we mean a virus that gives you an acute infection, soon after which you come down with ME/CFS.

    Of course, even though HHV-6B is already in most of us by the age of 2, it could still play a causal role in the development of ME/CFS; however, because we already have in our body from the age of 2, HHV-6B cannot be a triggering virus of ME/CFS.



    So this makes HHV-6A more interesting from the ME/CFS perspective: because it is found in much higher prevalence in the PBMCs of ME/CFS patients; and because as it is caught later in life, it might be triggering ME/CFS.
     
  3. Thomas

    Thomas Senior Member

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    Canada
    I know that Dr. Peterson is able to identify a subset of his ME patients (around 20%) who really just have a very active HHV6A infections. This group tends to have dramatic clinical improvements. However he checks blood, CSF, and tissue for confirmation.
     
    merylg likes this.
  4. Deltrus

    Deltrus Senior Member

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    I really wish we had better testing and drugs for this. I really want to try this avenue of attack for my moderate CFS. My dad had bell's palsy and I had very light bell's palsy symptoms. He's not my genetic dad but I was with him since I was a baby. I get hives with light exercise/heat. Might be HHV.

    Will that super fast virus testing thing be helpful here? Anyone have any updates on that?

    This one: http://www.cortjohnson.org/forums/t...-test-to-find-all-known-viruses-at-once.3060/
     
  5. Dan_USAAZ

    Dan_USAAZ

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    Phoenix, AZ
    @Hip, would you happen to know if the HHV-6A tests would still be accurate if the patient was currently being treated with Valcyte?
     
  6. Hip

    Hip Senior Member

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    Don't really know. I imagine it may make it harder to detect HHV-6A.
     

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