Hi Roger, Wow your story sounds familiar, that was me about 10 years ago. I also had low-level CFS for some years, but when I moved to Fairfax county and worked in the DC area for a few years I completely tanked. And went through the local experts, which led to short term gains but eventually some of the drug therapies made things much worse. I did eventually find a great CFS doc in N Virginia, John Hart, MD, a former OB/GYN who contracted a type of CFS and cured himself with 'Functional Medicine' which he now practices. I worked with Dr Hart (who has a practice out near Dulles and also in Fredericksburg, Stafford county, maybe one of those is not too far from you), and we took a more ecological approach, I got off most of my drugs. He ran tests that proved I was a pathological detoxifier. So he helped me find ways to support that. Then we worked on Lyme, Candida, and environmental issues, particularly mold. What is it about the toxic molds in the DC area? They were somehow tweaking my immune system, they seem to be much worse in DC than the rest of the eastern US. I used a dehumidifier and HEPA filtration, and that helped but eventually decided to move to a dry climate, which has really helped. I now have some mobility again, and am no longer mostly house/bed bound like I was in N. Virginia. If you want more info about Dr Hart, just PM me. Good luck!