Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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Heterozygous for A1298C and methylcobalamin

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by daniariete2000, Mar 23, 2015.

  1. daniariete2000

    daniariete2000 Senior Member


    I read this interesting blog and my attention was on that point:

    MTHFR 677 measures:
    Avoid folic acid. Use L methylfolate (metafolin) or folinic acid instead, N acetyl cysteine, SAMe, and B12 (methylcobalamin or hydroxocobalamin or adenosylcobalamin).
    Methylfolate is best absorbed on an empty stomach. Use only the L form and avoid the D form.
    Consider eliminating gluten and dairy.

    MTHFR 1298 measures:
    BH4 levels can be best increased by 5-methyltetrahydrofolate (5-MTHF) and vitamin C (ascorbic acid). 5-MTHF helps scavenge peroxynitrite (ONOO) and increases vascular BH4 and BH4/total biopterin ratio.
    Supplementation of magnesium, copper, vitamin B6, SAMe, B12 (as hydroxocobalamin), vitamin A, a-ketoglutaric acid, tyrosine and 5HTP may also be helpful.
    Other helpful measures may include eating a lower protein diet (as ammonia depletes BH4), limiting L-phenylalanine intake.

    Those who are compound heterozygous can combine helpful measures for both MTHFR 677 and 1298. "

    My question is :

    Since I'm Heterozygous for A1298C , why I should avoid methylcobalamin ?


  2. Gondwanaland

    Gondwanaland Senior Member

    There will be too much serotonin to be degraded, increasing ammonia and depleting BH4
    An approach like caledonia's "Start low and go slow" (linked in my signature "Freddd's protocol") is more indicated in that case
  3. ahmo

    ahmo Senior Member

    Northcoast NSW, Australia
    @daniariete2000 I've really thrived on Freddd's Protocol, using MB12, Mfolate, AdB12, and L-Carnitine Fumarate.
    Gondwanaland likes this.

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