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HERV env antibody treatment for MS: phase IIa trial completed

Discussion in 'Other Health News and Research' started by natasa778, Nov 24, 2013.

  1. natasa778

    natasa778 Senior Member

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    London UK
  2. natasa778

    natasa778 Senior Member

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  3. leela

    leela Slow But Hopeful

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    Could someone please explain why it is okay to consider retroviral causation for MS but totally taboo for ME?
    Hmm?
    Overstressed and vli like this.
  4. Daffodil

    Daffodil Senior Member

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    hi leela. what makes you say it is taboo for ME? HIV medicines have helped a lot of people with ME. Dr DeMeirleir and Dr. Lombardi recently published a paper suggesting that HERV env protein is the cause of CFS.

    about GeNeuro's MS drug:

    "So far, 10 patients have been dosed with the agent, he said. Single doses at 2 or 6 mg/kg have been administered to five patients each.

    In the low-dose group, four showed no change in MRI lesions 4 weeks after dosing compared with baseline, with one patient showing a decrease. One patient with primary progressive MS had a "decrease of inflammation," Curtin said.

    Only four patients in the high-dose group had their 4-week MRI scans when Curtin finalized his presentation, with all four showing stable lesions.

    A total of 16 adverse events were noted in the 10 patients, ranging from neurological symptoms such as tremor and limb spasticity to bradycardia, tachycardia, and bladder infection.

    Patients in the trial are now receiving additional doses and the firm expects to have final 6-month results from the study in September."
  5. leela

    leela Slow But Hopeful

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    Oh, Daff, I was just referring to the historic hysterics regarding research in this area. For a while there it was a career death-knell to even mention it. Many of those trialling antiretrovirals in the wake of XMRV were vilified for doing so.
    That's all I meant.

    I was indeed pleased to see the HERV reactivation paper.
    Bob and Daffodil like this.
  6. Bob

    Bob

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    Very interesting. Thanks for posting, natasa. It's a 'phase 2' trial so it's early days, but one to keep an eye one.
  7. natasa778

    natasa778 Senior Member

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    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765820/
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  8. Daffodil

    Daffodil Senior Member

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    even though I think this was just a low dose safety trial, I heard that one patient's MRI improved. no side effects.

    phase 2b planned to start in first half of 2014...maybe already started

    I am referring to monoclonal antibody trial
    Last edited: Jun 15, 2014
    natasa778 likes this.

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