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Hereditary Cerebral Small Vessel Disease

Discussion in 'Neurological/Neuro-sensory' started by merylg, Nov 26, 2012.

  1. merylg

    merylg Senior Member

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    Sydney, NSW, Australia
    The cause of this has been found to be a mutation in the High Temperature Requirement-1 (HTRA1) gene. In the aberrant process, mutant HTRA1s have been shown to lose their protease activity leading to an increase in TGF-Beta family signalling.

    TGF-Beta family signalling defects are associated with scoliosis & alopecia.

    TGF-Beta family signalling defects are also associated with Marfan's/Loey Dietz Syndrome.

    http://www.ncbi.nlm.nih.gov/pubmed/22277429

    Angiotensin 1 Receptor Antagonist...a potential therapeutic...(already in use I believe)

    Wondering how many with ME/CFS have a family history of vascular dementia? This could be part of the picture.

    http://www.ncbi.nlm.nih.gov/pubmed/21301034

    Hmmm...also thought to be associated with degenerative disc disease...
    GracieJ likes this.
  2. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    Hmmm, interesting. One of my brothers has vascular dementia.
  3. merylg

    merylg Senior Member

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    My father had this history too.
  4. Countrygirl

    Countrygirl Senior Member

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    UK
    My mother has vascular dementia and I have scoliosis, degenerative disc problems and alopecia. My brain scan after one of my stroke-type episodes showed lesions in the right basal ganglia.

    I am not looking forward to the future then. :ill:

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