A few months ago I began taking heparin injections to see if it would help. I understood that it is not a curative measure, but may improve symptoms, and I figured it was worth a shot (ha ha). I didn't do testing for hypercoagulability, since my doctor basically said that either way it went heparin could end up being helpful. Also I had a history with sublingual heparin, which helped considerably with brainfog however the sublingual route became too painful for me so it was ceased years ago. I did my research and took the plunge. So far my experience has been definitively positive, though not what I was expecting. I have no change in brain fog, however it helps significantly with short-term memory problems. Before my daily injection my short-term memory is absolutely shot, as in, I'll have the full syringe and ice pack in front of me and such and then forget about it for a few minutes, notice it again and think, "Oh hey, while I have this stuff out, I may as well do my daily injection..." and then, "Oh yeah, right, that's why I got them out in the first place." At first I was concerned the heparin was making my memory problems worse, until I noticed that all the issues I was having were always before the injection, never after. The other very significant thing is that it alters my state of fatigue. I'm not quite sure how else to put that. I still feel significant unrelieved exhaustion, but some days after injections I'm getting up and walking around just because I feel like moving...and it feels good to move around. And tasks such as raising a glass of water to my lips become easy instead of the toiling difficulty they are otherwise. I've even got sore muscles from too much exercise without having PEM!!!! Oh, that's huge for me, I can't even begin to tell you. I'm housebound and about 90% bedridden, so this is a very significant change for me. But it doesn't last all day, and I still have bad days. Some days there's a night-and-day difference, where before the injection I'll be doing horrible and within 15 minutes afterwards I'm dancing around just because it feels so good to move. Other days, the injection doesn't seem to make much of a difference at all. I'm still trying to figure out the patterns, but it seems that when I'm at my optimal, that is, well rested, nothing stressful going on, etc, then there's the significant difference, but when I'm recovering from something major the heparin appears to make no difference. However, again, I'm still not sure. It's a strange kind of improvement, because on the one hand I don't actually feel a whole lot better, I just have a higher capability of function and short amounts of exercise at key times is enjoyable. This is huge for me, but I want to emphasize that it's no panecea. Yesterday I overdid it with an animated hours long conversation with someone, by the end of which I was sweating profusely and vomiting foam...my body was really needing to rest. I had to take pain meds to be able to sleep. But today, even though a whole side of my body is sore from sitting in an awkward position, I am not suffering from PEM as I expected to. I'm not unaffected - pain levels are higher and I'm sweating like crazy with a low grade fever - but my fatigue is a more functional kind of exhaustion, one that means I can get up and do things with a little extra flair of energy and I'm still okay. Some days I forget to take my heparin at first, and later in the day I start asking myself, "why am I doing so horribly right now? What did I do to cause this?" I remember heparin, take it, and don't think about it any further because I'm too busy with my day to think about it. Heparin only stays in the system for 6-7 hours. Currantly I only dose once a day, when I wake up but I've received permission from my doctor to try twice a day if/when I want to. I'm curious to see if it would help with sleep. I'm also really excited about the potential long-term effect of improving muscle tone. Delayed-onset muscle soreness means the muscle is getting stronger, and I figure strong muscles can work with less fatigue than weak muscles. So even though I went into this expecting no long-term improvements, I cannot help but hope for a little bit of that. Does anyone else have experience with heparin? Anyone have questions I might be able to answer?