1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Give ME the Money
Graham McPhee spells out some of the cold, hard facts about the dismal state of ME research and politics, and has some suggestions as to what we can do about it ...
Discuss the article on the Forums.

help with methylation profile please

Discussion in 'Genetic Testing and SNPs' started by evat, Aug 6, 2014.

  1. evat

    evat

    Messages:
    1
    Likes:
    0
    My name is Eva, I am 45 years old and live in Norway and have problems with CFS. Reading about methylation has made me feel like, for the first time, that there is hope. A problem in Norway is that methylation-problems are still relatively unknown. Currently, I have not found any doctors who deal with these issues.

    My husband and I tokk the 23andme gene test and this is our methylation profile. I know there are many resourceful people on this website, and I would truly appreciate it if anyone could look at these results and give me some advice. Thank you kindly for your time.

    Here are my husband's results:
    Homozygot:
    MTHFR A1298C ++
    COMT V158M ++
    COMT H62H ++
    VDR Taq ++

    Hetrozygot:
    MTR A2756G +/-
    MTRR A66G +/-
    CBS C699T +/-

    Here are my results:
    Homozygot:
    MTHFR A1298C ++
    COMT V158M ++
    COMT H62H ++
    VDR Taq ++
    BHMT-02 ++
    BHMT-08 ++
    AHCY-01 ++
    AHCY-19 ++

    Hetrozygot:
    MAO-A R297R +/-
    MTR A2756G +/-
    MTRR A66G +/-
    MTRR A664A +/-
     
  2. Helen

    Helen Senior Member

    Messages:
    569
    Likes:
    584
    Hi @evat , welcome to the forum

    Both you and your husband would probably benefit from B12 and folate-supplementation. Your MTHFR A1298C mutation is pretty rare, but decreases your enzyme activity to about 50 % (according to this study http://www.ncbi.nlm.nih.gov/pubmed/10911766).

    Also your MTR and MTRR mutations probably have an impact on your need for B12.

    Did you get homocysteine or methyl malonic acid (metylmalonsyra) tested? B12 in blood? Folate? MVC? Iron and ferritine? These tests could reveal deficiencies. I guess that it is also possible to get genotyped (gene tested) for MTHFR C677T and A1298C via a Norwegian lab. In Sweden it is, and my experience is that doctors take this seriously. I had my 23andme test completed with this more accepted gene test.

    Maybe the Balder clinic in Oslo could help? @deleder2k might know too where to get help.

    I´ll PM you in Swedish- hopefully easier for both of us ;)

    Best,
    Helen
     
    Last edited: Aug 6, 2014
    Critterina and evat like this.
  3. deleder2k

    deleder2k Senior Member

    Messages:
    275
    Likes:
    911
    Oslo, Norway
    Have you tried dr. Mette Sophie Johnsgaard at Balderklinikken, Oslo? She's into Imunovir, Gammaglobulin, high-dose B12 injections, Gaba 2, HTP-5 etc.
     
    evat and Helen like this.

See more popular forum discussions.

Share This Page