Ray B, You are compound heterozygous for MTHFR (C677T and A1298C). This is the second-worst combination of those two SNPs. This can make for several health difficulties. You may want to look into it further, beyond this site. There are some informational links in a thread that I put together here (the link to it is below my signature line -->) As a first port of call, you might want to look at Dr. Benjamin Lynch's site www.mthfr.net, which is just about the most comprehensive available on the internet for MTHFR. (And watch his video, which is linked to in my big list of links.) I am also compound heterozygous for MTHFR, and I found a big difference in avoiding all supplements that have folic acid in them, and avoiding all foods that are fortified with supplemental folic acid. That is not such an issue in the UK as it is in the US, where it's a law that certain foods must have artificial folic acid added to them. But I do think the UK might have some folic-acid fortified foods, so you should read the labels, and be especially wary of grain products like boxed breakfast cereals, store-bought loaves of bread, lunch sarnies from shops, the crusts on restaurant pizzas, etc. I'm not saying it's a necessity for you, I am just saying just that my totally avoiding folic acid for the last couple of months has made a noticeable difference to me. You might want to have your daughter (and other children, if you have others) tested, either by 23andMe also, or maybe just for MTHFR (although I think that narrower test would be more expensive than just doing 23andMe). The reason I say that is your MTHFR mutations could have been passed down to her, and beyond all the other health issues they can cause, they can cause real difficulties with getting pregnant, with carrying the baby to full term, and with the physical health of the baby. There is also a strong correlation between having MTHFR mutations and being diagnosed with childhood autism. I spent three days in Durham a few years ago. It goes without saying that it's a beautiful place with a special atmosphere!