COMT V158M rs4680 AA +/+
COMT H62H rs4633 TT +/+
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 TT +/+
VDR Taq rs731236 AG +/-
MAO A R297R rs6323 T +/+
ACAT1-02 rs3741049 AG +/-
MTHFR C677T rs1801133 AG +/-
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 GT +/-
MTR A2756G rs1805087 AA -/-
MTRR A66G rs1801394 AG +/-
MTRR H595Y rs10380 CT +/-
MTRR K350A rs162036 AG +/-
MTRR R415T rs2287780 CC -/-
MTRR A664A rs1802059 AG +/-
BHMT-02 rs567754 CT +/-
BHMT-04 rs617219 AC +/-
BHMT-08 rs651852 CT +/-
AHCY-01 rs819147 TT -/-
AHCY-02 rs819134 AA -/-
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 AG +/-
CBS A360A rs1801181 GG -/-
CBS N212N rs2298758 GG -/-
SHMT1 C1420T rs1979277 GG -/-
You have two First Priority mutations, which are ACAT and CBS. ACAT is one of the "leaky gut" genes. If you have food allergies and sensitivities, or if you start methylation and get a high need for potassium and/or magnesium, you have leaky gut, and should stop and treat that first. The other thing that ACAT can cause if expressed, is kidney stones. Yasko has a super duper all in one supplement for ACAT that also includes BHMT, which you also have. So that one would be appropriate in your situation. It's kind of expensive though. You may be able to get away with taking ox bile (bile salts) and doing a low oxalate diet.
The next mutation to address is CBS. First you'll want to see if it's expressed. Problems with sulfur foods or meds, or problems with a stress/anxiety/cortisol response when you start methyl supplements is a clue that this is expressed. You can do testing to see if ammonia and/or urine sulfate are high. Most people opt to just do the urine sulfate strips to save money. So, if this is expressed, you'll need to do a low free thiol diet, and take supps to lower ammonia and sulfate for a couple of months. Heartfixer has an excellent CBS protocol which I used successfully (except I did the Free Thiol diet, and didn't take any of Yasko's RNAs).
All of this preparation may take many months, so you're going to need a lot of patience. Finally, then you're ready to start on methylation supplements. You have two MTHFR mutations, so definitely supplement with methylfolate. You have a lot of MTRR (B12 recycling) mutations, so you'll need some B12. You have BHMT mutations (secondary methylation pathway), so some TMG (tri
methylgylcine) for that.
With COMT V158M +/+ and VDR Taq +/-, Yasko suggests hydroxycobalamin and adenosylcobalamin. In other words, methylcobalamin is likely to cause mood swings, so stay away from that.
VDR Bsm is the Vitamin D Receptor which is +/+, so it's likely to be low. Get your vitamin D levels checked and supplement with that if necessary.
With MAO +/+ it's likely you'll have some mental health issues. You can supplement with 5htp to boost serotonin. Just getting methylation going again will make neurotransmitters, so this alone might be sufficient.
Note: If you're already on an SSRI or other similar psych med, don't take serotonin supplements at the same time. At some point, when you have methylation going and are making neurotransmitters again, and have GABA and glutamate balanced and so forth, you can very gradually start to wean off any psych meds. See the Paxil Progress forum for more info on how to do this properly. If you come off too fast (which will be any schedule a doctor will give you, you can get into a horrible withdrawal syndrome and have to go back on the med - speaking from personal experience here. I lost a whole year getting messed up with this.)
Finally, read/watch all the links in my signature, and try to get a good handle on things before diving in. Take each SNP one at a time in order, so you don't get overwhelmed. As Yasko is fond of saying, this is a marathon, not a sprint.