Hi, After getting genetic testing done and identifying several mutations I've started supplementing. I've started using @Freddd's protocol as my primary reference and have seen some results although overdid it a bit with 5-MTHF (see other post, lesson learnt). My confusion now comes from having processed my 23andme data through a site called NutraHacker. That has given me a table for my results and suggestions for what to take and what to avoid. For some mutations I'm told to encourage Hydroxy B12 and avoid Methyl B12, Methyl donors. For others I'm told to encourage Methyl B12 and TMG which is a Methyl donor. I'm definitely seeing benefits from taking Methyl B12 and have also been taking some TMG and feel good when I use it and notice something is missing on the days I don't. Should I also be looking to take Hydroxy B12? It is recommended against COMT genes (rs4633 and rs4680).