Can You Come for a Visit? My ME/CFS Says No
My daughter and son-in-law just had a baby last week. We are thrilled. But we won't be able to see the baby or hold her any time soon. We won't be able to take over little gifts or help out with housework or babysitting.
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Help please ANY GENE GURUs on site.

Discussion in 'Latest ME/CFS Research' started by flybro, Jan 10, 2010.

  1. flybro

    flybro Senior Member

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    pluto
    Can someone please try to explain what this paper is saying about the NUPIF2 gene which I have highlighted.
    Does it have any signifigance to CFS or is it just there? Sorry its not clear press Ctrl & + to zoom in.

    Its taken form page 1175 from Kerrs study here http://128.121.104.17/cfs-inform/Genes/kerr.etal08.pdf
    Any help would be much appreciated.

    [​IMG]
     
  2. flybro

    flybro Senior Member

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    pluto
    Just bumping this up incase a any Gene gurus have missed it.
     
  3. ALL I can tell is the expression of this gene is significantly upregulated in cfs patients compared to controls it seems to be associated with fragile x syndrome or at least a sign of chromosomal damage in areas of the chromosome responsible for normal neuron function in areas such as working memory or other major cognitive function----it could theoretically be associated with the neurocognitive problems associated with our illness.Nufip2 unpegulation will produce symptoms similar to a neurodenerative disorder which would normally be inherited even in the absence of a genetic defect------what causes the upregulation of this gene in these patients is anyones guess but it is possible that an inserted retrovirus could cause it
     
  4. Advocate

    Advocate Senior Member

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    U.S.A.
    I hope we get some answers from the study Mikovits and Kerr are doing together. (Together?)
     
  5. flybro

    flybro Senior Member

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    pluto
    thank you so much,

    and OMG

    i think my daughters autism is fragile x, she has the odd features of fragile x.

    I was investigated for turners sydrom as a child. but fragile x was unknown back then. I have the simian crease.

    WOW.

    I think the fragile-x could well be XMRV damage, its a repeating gene sequence mutation, depending on how many reapets as to how affected one might be. I wondered if it could be the virus writing itself into the same area repeatewdly.

    I've been trying to get this question answered since october last year.

    I could hug you.

    My paternal grandmother had atypical MS.

    infact
    :hug:
     
  6. flybro

    flybro Senior Member

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    pluto
    Oh and I am awaiting a reffereal to get tested, as i realise I am likely a carrier.

    I only leaent about fragile-X october last year, my daughter is 21.
     

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