Can anybody please tell me about their experience/success with migraine preventatives? Anybody using cymbalta or lyrica for pain management without experiencing significant side-effects? I have no way of knowing if the Mestinon I started 10 days ago for my POTS symptoms is working b/c the 2-3x wk migraines are debilitating. Sometimes they last 2-3 days giving me respite for only a few more days until the next migraine appears. I was quite hopeful and my mood was relatively good until as of late. The increasing frequency of migraines is causing depression to set in. I need help with pain management asap. Thanks to any suggestions/advice.