Hello everybody This is my first post here, so I will introduce myself - Andriy, live in Kiev, Ukraine I struggle with anxiety, IBS-C symthoms, fevers. Local healthservice happens to be useless in my case, so I take investigation in my hands. As I understand I have some nastiest SNP combinations. Enlight me please, is it as serious as I think ? Gene & Variation rsID Alleles Result COMT V158M rs4680 AA +/+ COMT H62H rs4633 TT +/+ COMT P199P rs769224 GG -/- VDR Bsm rs1544410 TT +/+ VDR Taq rs731236 GG -/- MAO-A R297R rs6323 GG -/- ACAT1-02 rs3741049 AG +/- MTHFR C677T rs1801133 AA +/+ MTHFR 03 P39P rs2066470 GG -/- MTHFR A1298C rs1801131 TT -/- MTR A2756G rs1805087 AG +/- MTRR A66G rs1801394 GG +/+ MTRR H595Y rs10380 __ no call MTRR K350A rs162036 AA -/- MTRR R415T rs2287780 __ no call MTRR A664A rs1802059 GG -/- BHMT-02 rs567754 CT +/- BHMT-04 rs617219 __ no call BHMT-08 rs651852 TT +/+ AHCY-01 rs819147 CT +/- AHCY-02 rs819134 __ no call AHCY-19 rs819171 CT +/- CBS C699T rs234706 GG -/- CBS A360A rs1801181 AA +/+ CBS N212N rs2298758 __ no call SHMT1 C1420T rs1979277 __ no call If it helps I have measured folic acid 16.7 (5-17) serum B12 (cyanocobalamin) 360 (191,0–663,0) As I understand folic acid and cyanocobalamin levels are not really relevant in my situation Thanks in advance ) P.S Should I do homocysteine test ?