Help interpreting results...

[Donna Marie]

Just got my 23andMe results and ran them through livewello app. Can someone with knowledge please have a look.
I really can't figure this out on my own, thank you in advance to anyone willing to give some advice or direct me in the right direction. https://livewello.com/snps/share?for=donna

 

[PeterPositive]

Instead of attaching the raw data here, it would be better to run the data into Genetic Genie or similar website and post the results here.

Maybe someone with an account on livewello.com will help, but the former option would be more convenient.

cheers

 

[Donna Marie]

Gene & VariationrsIDAllelesResult
COMT V158Mrs4680AG+/-
COMT H62Hrs4633CT+/-
COMT P199Prs769224GG-/-
VDR Bsmrs1544410CT+/-
VDR Taqrs731236AG+/-
MAO-A R297Rrs6323GT+/-
ACAT1-02rs3741049GG-/-
MTHFR C677Trs1801133AG+/-
MTHFR 03 P39Prs2066470GG-/-
MTHFR A1298Crs1801131TT-/-
MTR A2756Grs1805087AG+/-
MTRR A66Grs1801394GG+/+
MTRR H595Yrs10380__no call
MTRR K350Ars162036AA-/-
MTRR R415Trs2287780__no call
MTRR A664Ars1802059AG+/-
BHMT-02rs567754CC-/-
BHMT-04rs617219__no call
BHMT-08rs651852CC-/-
AHCY-01rs819147TT-/-
AHCY-02rs819134__no call
AHCY-19rs819171TT-/-
CBS C699Trs234706GG-/-
CBS A360Ars1801181AG+/-
CBS N212Nrs2298758__no call
SHMT1 C1420Trs1979277__no call


This is my Analysis from Genetic Genie

 

[Valentijn]

@Donna Marie - Having MTRR A66G as +/+ means that methyB12 recycling is at about 30% of the normal rate. Supplementing B12 might help with that. Some people have trouble tolerating methylB12 supplementation, so hydroxoB12 can be a good alternative.

 

[Donna Marie]

Thank you Valentijn, had several bad weeks with methylB12 and Super Bcomplex, I am new to all this and am having a hard time understanding. Would my results show a problem with folic acid?
I have white matter lesions in my brain, DX with Multiple Sclerosis 2008 with a negative spinal tap for MS. I have just begun to find out about B12 and methylation.
Also I have very low vitamin D.

 

[Valentijn]

Would my results show a problem with folic acid?

No, there's no indication that you have any problem converting folic acid to methylfolate.

 

[Critterina]

Interesting! I usually agree 100% with @Valentijn. Well, almost always. This time I would think this:

The MTHFR C677T rs1801133 AG +/-

would indicate that you'd possibly benefit from supplementing with methylfolate. I know it's not as bad as a +/+, because you'd still be making methylfolate at about, what, 65% of normal? opinion only.

 

[Valentijn]

Interesting! I usually agree 100% with @Valentijn. Well, almost always. This time I would think this:

The MTHFR C677T rs1801133 AG +/-

would indicate that you'd possibly benefit from supplementing with methylfolate. I know it's not as bad as a +/+, because you'd still be making methylfolate at about, what, 65% of normal? opinion only.

Whoops, you're right ... I missed that in the bad formatting

 

[Critterina]

Hah! My friend Valentijn!

 

[physicsstudent13]

I really think I may have multiple sclerosis with vision problems, dizziness when walking, facial palsy, hearing loss, can't speak sometimes and have severe fog.
So you are diagnosed by symptoms alone or MRI contrast since the blood brain barrier is open in MS?
There is a CPNhelp.org site where some patients are claiming cures and complete remission of MS by antibiotic protocols.
this sam-E is supposed to increase myelin I think but it is really expensive.