I've never been able to determine whether I do or do not have issues with methylation. I've tried both Rich and Freddd's methylation protocols, several times over the years, with little measurable success. I don't know if it's an issue with missing cofactors, detox reactions or if it's just something that doesn't apply to me. I find that much of the information for this approach is so convoluted and scattered all over the forum that I basically gave up trying to figure it out. Currently, I've been following the "Unfolded Protein Response and A Possible Treatment for CFS" thread with great interest. I'd like to try the treatment proposed by @mariovitali but he mentions that methylation may be some sort of limiting factor so I'd like to rule this out before proceeding with his recommendations. I was wondering if anyone that was knowledgeable about methylation defects would be so kind as to look at my 23andMe results and let me know if it's something I should even bother to concern myself with... Genetic Genie Methylation Profile Genetic Genie Detox Profile Thanks.