Whatever goes out on my methyl cycle w/o hormones (or with insecticides that intercept the hormones) - maybe CBS - I wanted to say that the strategy of extra TMG and adrenal glandular to deal with it is not very robust. DHEA is normally robust (except that insecticides anyway can take it out) for I can get 12 hours free of neurological symptoms out of it and I can manage something like that. W/O hormones on my side, what happens is the methyl cycle and adrenal assists I can manage to tame the symptoms with only last a few hours and as they wane it is not a sudden drop so you can go into a black hole forgetting the time, and forget to take the next supplement so then you wind up really hosed. It is a very unstable strategy since the first symptoms are neurological from which its had to step outside yourself and "wake yourself up" so to speak to go get the next dose. I can only list some symptoms of the methyl cycle w/o hormones with these genes as I just forget these things until a few minutes later I experience another and another. But they could be described as wired and tired I suppose since I normally sleep like a log but suddenly am having to take melatonin and I would say number 1 symptom is tension, but also skin can't stand to be touched, muscles feel "pulled" w/o exercise, anxiety, depression, worse than ever about losing all sense of time. So please do not think that what I listed a few screens ago as taking care of these symptoms is a good suggestion -- it's not a stable solution, despite that it works. The stable solution for me is hormone replacement, specifically DHEA (although I am pursuing estrogen replacement and currently am on a small startup dose. No one has commented on the use of hormones to fix these genetic issues. Has anyone else tried this? It works like magic for me. I doubt it would be able to work without a sound nutritional protocol behind it because it can't make up for deficiencies, but I think it helps regulate one or more of the genes in my makeup, specifically CBS and possibly others associated with BH4 (since it banishes those symptoms also). This is the main thing I wanted to clue some of you in about because women have cycling hormones and so they have a lifetime of chances to compare life with and without hormones and see their effect. But men's just wane later in life and they usually don;t realise the role their hormones play in the health conditions that arise. For instance, when I first got high blood pressure, it was measureable to occur only during low estrogen (PMS). Then my estrogen got lower and it occurred all the time. These tension-that-won't-go-away and can't sleep symptoms have been part of EVERY low hormone (PMS) period of my life. So it was easy for me to see that hormones would help. Maybe not so easy for some of you. I don't know why no one has even asked about this? Has anyone else tried it? I did ask Fredd about it and he said he also takes pregnenolone 100mg and DHEA 25mg.