Hello friends, I finally got my Yasko results back a week ago and have been going crazy -- literally -- trying to figure it out, sort out the conflicting information, especially regarding the CBS upregulation issue, which I unfortunately have. I thought for sure I'd have the MTHFR(!) problem, but only on one mutation. Yasko says to cut protein way back, to use yucca, to avoid SAMe, methionine, taurine, MSM, and all other sulfur supps -- plus cut back on sulfur foods like eggs, which I was told by another practictioner I needed to increase! She also says that not only is sulfur and sulfites a problem, but SULFATE is a problem too, which totally contradicts Rosemary Waring's research w/autistic/ASD folks where she found the vast majority were low in sulfate and that sulfate helped them. I've lost 15 lbs in a year -- predicted in a way, by the methylation panel/nutreval results a year ago which showed I was using my own muscle/fat for fuel. So I need to turn this around, or at least STOP it from continuing. I understand the sulfite/ammonia connection -- and my ammonia was high -- as was my taurine -- so can work on that, but I just don't understand how two different researchers can have such conflicting advice. Here's my results: COMT V158M +/-, COMT H62H +/-, VDR Taq+/+, VDR Fok +/-, MAO A +/+, MTHFR C677T +/-, MTR A2758G +/-, MTRR A66G +/-, BHMT 2-4 +/-, CBS A360A +/+ THANKS IN ADVANCE FRIENDS, Dan p.s. Also Jill James did a study that showed the mb12 and folinic helped those with CBS issues -- they concluded that "Treatment with methylcobalamin and folinic acid seems to have rescued GSH synthesis in this cohort of children (with CBS upregulation) at the expense of transmethylation metabolites." Not sure what she means by the latter... http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647708/?log$=activity Any comments/suggestions are greatly appreciated!