My aunt is 69 years old. She developed ME shortly after a trip to India, although she has had numerous illnesses suggesting a poorly functioning immune system for years, together with thyroid issues when in her 20s ( partial thyroidectomy), and symptoms of a hypoactive thyroid response now. She feels it may have been the travel vaccinations that tipped immune response over the line and ME followed. She has osteoporosis too. She has been bedbound for nearly 2 years and had the ATP profiles test around Easter and this provided a score of 0.11 reflecting how ill she was - she has deteriorated since then. Testing for toxins highlighted significant lead presence ( she carries haemochromotosis gene and this may affect lead too - there seems to be a correlation as you age). She cannot detox with DMSA as her body cannot cope with it, even on a reduced dose.( 8 tablets/week) She tried the Optimum clinic, and I think she found the meditation/ stress and diet helped for a while. She has been in touch with Dr Myhill following the ATP Profiles and test - the supplement regime is based on feedback. Her GP is hopeless ( even with the MEA book) She follows the supplement regime below, but this is not providing any improvement - she is currently getting worse. She has excrutiating permanent headaches and symptoms of POTS. She cannot tolerate B vits - particularly B12 ( went temporarily blind for 20 mins on 2 occasions after taking) Multi Mineral Mix 3gm Acetyl-L-Carnitine x2ml Vitamin C500 X1 Multi Vitamins &Minerals X1 Marine Ethyl-EPA 70 x2 Niacin 500 mg X1 Poyzyme Forte X1 Ubiquinol 100 mg x2 Pregnenolone 25 mg X 1 Hemp oil x1Tbl spoon Melatonin 3mg x2 Magnesium .5ml injections twice daily I feel that there are significant methylation issues ( but I don't know enough about it), and potenitally SNPs that may affect things. I have persuaded her to do a 23 and me test and we await the results. My aunt's main carer is her elder sister (71)- they both played a huge part in my life after my parents divorced and it is horrible to see things playing out without the knowledge to help. Can anyone suggest any ways forward - we are really at the stage that we will try anything.