Hi guys, I’ve been reading this forum with interest and wondered (hoped) some people might be able to offer some thoughts as things are extremely rough for me at the moment. I’m quite a severe case with a triad of issues stemming from I believe the adrenals, liver and gut. Standard bloodwork from my GP comes back negative. I experience the following symptoms.... - Hypoglycemia (somewhat diet controlled) - Constipation - Gas - Bloating - Almost complete food intolerance (starch, fruit, dairy, eggs, yeast, grains) - Histamine intolerance - Fatigue (although not bedbound) - Multiple Chemical Sensitivity - Shortness of breath and air hunger (came on after gas exposure. Now chronic even when exposures are removed) - Liver/gallbladder throbbing ache - Adrenal/kidney throbbing ache - Brain fog - Panic attacks - Muscle ache (shoulders/neck/chin) - Severe insomnia - Skin pigmentation patches - Light sensitivity I’m almost completely non functional with these symptoms. I will have to lay in bed unable to think about anything else besides my breathing for hours. The severity of these symptoms has progressed over 4 years. What took me from tolerable to non-functional was a gas exposure about 4 months ago. That’s when my liver really felt like it had packed in. My digestion is horrible. I can’t digest any carbs but feel I need them. White rice spikes my blood sugar too much. Food ferments and putrify’s in the gut and I seemingly have limited peristalsis to move waste through the body. Certain things like magnesium and betaine HCL help a little but not enough. I’m still not digesting my food and getting weaker as a result. Diet is super clean. I have tried probiotics on occasion with limited success. My liver is at the core of my issues. I can feel it chronically under my ribcage, even more so when I constipated. I believe my MCS is purely a liver detoxification problem with fast phase 1 and slow phase 2 activity. My supplement tolerance is terrible. Standard adrenal supplements don’t ‘clear’ from my system and they leave me wired even at small doses. I believe this is likely liver related. Liver supplements like Milk Thistle ‘stir up’ toxins but they are not eliminated effectively, typically leaving me worse off. I strongly believe I am an under-methylator. My gut feels very raw, inflamed and pathogenic. Because of very weak adrenals and worsening of nervous system symptoms such as air hunger, I’ve been unable to tolerate anti-fungals or any forms of detox. I have intolerances to eggs and dairy, and constipation from starch, fruit, grains and legumes. I haven’t had a histamine test but react horribly with extreme brain fog, crawling skin and increased salivating to fermented/aged foods. I only made backwards progress when trying the GAPs diet as I couldn’t tolerate sauerkraut, kefir, beet kvass or bone broth but tried them anyway. Some points to note..... - I have no fillings - I was born with jaundice and premature and grew up with asthma and acne, for which I used inhalers and antibiotics for a long time - I developed a carb addiction when I first became ill 4 years ago, but remain very slim - Trying an asthma inhaler recently sent me into a seizure and severely damaged my adrenals. - My environment is mostly non toxic. The construction is 5-10 years old with no recent development work. No odours from cleaning chemicals, laundry, air fresheners etc. The house is gas centrally heated though (pretty much impossible to avoid). I’ve tried lots of things, but rarely have been able to stick the course, either due to adverse reactions that are too uncomfortable, or sensitivities to supplements. I’m stuck in the following loop.... Digestion is poor due to weak adrenals and gut dysiosis –> Unable to tolerate any forms of ‘die off’ due to nervous system instability, air hunger, probably due to weak adrenals –> unable to tolerate supplements to assist adrenals due to poor liver clearance and/or gut issues –> do not have the adrenal strength to detox the liver and the channels of elimination are not open anyway. I’m in desperate need of help. I’m particularly interested in those that can familiarise with the ‘liver ache’ and how to overcome it. I need to start digesting my food somehow and get some additional bassline nutrient if possible to stabilise me. Does anyone have any advice on this? Many thanks for reading!