Hi everyone! I have a kind of urgent request for help figuring out methylation. I've been sick for almost 2 years and haven't been able to tolerate most medication since then. I had some success with improvement through lifestyle and natural remedies so I didn't address it...but now I have a sinus infection and it's not going away, so I need to take an antibiotic. It doesn't seem to be terrible right now, so hopefully I have some time to figure this out. I've had the exact same reaction to a bunch of medications: Flagyl, cefpodoxime, Valtrex, Augmentin, and azithromycin. After a couple of doses (or sometimes just one), I start to get anxious. If I continue, it builds to pretty much constant panic attacks, insomnia, paresthesias (I have peripheral neuropathy and it makes it really painful), jumpy vision, etc. Basically just all nervous system symptoms. From what I read, it sounds like excitotoxicity (which I actually don't have much of a problem with usually). So I've tried to figure out what caused this and I believe it may be a methylation problem (although if anyone else has an opinion, I'd be open to that too!) These aren't allergic reactions - I had my IgE level checked during one of the reactions and it was normal. I'm fairly sure it has to do with how my body is processing the medication. I say that because I took cefpodoxime once during a very good period - closest I've come to remission - and tolerated it just fine. A month later, I had a horrible reaction. And the way it builds it my system...I can tolerate small doses of things but as I increase my body just rejects it. So first question - if this is a methylation problem, what am I risking if I try pushing through the symptoms? And second - could someone help me figure out what I need to be taking to fix this? If there's anything I could in the short run to make an antibiotic more tolerable and/or a full plan for fixing this? This is something I really wanted to figure out for myself, but I don't think I have time to learn it fully since I need to address this fairly quickly. I've done 23andMe and have Genetic Genie results, although I'm not sure how to post them there. I'll try to figure that out. Any help anyone could give...I would be so appreciative! Thank you!