I am compound heterozygous for MTHFR, and have been doing the best I can to figure things out for myself; I have been unable to find any kind of practitioner near to where I live (the wilds of Yorkshire in England) who has any clue whatsoever about methylation issues. I'm at the point where I really need some advice, but don't know who to ask. I have been taking 800 mcg of Methylfolate (Solgar) and 5000 mcg of Methyl B12 (Jarrow) daily for several months now, since getting my original results, along with a few other carefully chosen supplements. A few weeks ago I read Fredd's protocol, and introduced some new things, specifically Potassium and Fish Oil with high Omega 3. I also took B-Right (Jarrow) but thought I was overdoing the B12 dose given that it was on top of the Methyl B12. I ordered the 'country life' supp (sorry, can't remember the particular name right now) but decided against it when I realised it contained folic acid which, of course, is out of bounds for me. When I started on the methyl forms, I felt like a completely new person; energised, sleeping really well, amazingly good mood etc, but over time this has gradually dissipated, to the point where I am beginning to feel like I am crashing. It may be that this is part of the detox process and I have to work through it, but I'm concerned that I might be doing something wrong supps wise, through ignorance. If anyone could take a look at my genetic genie results below and comment, I would be very, very grateful. If it helps, as well as the things listed above, I'm taking the following: vitamins C & D Magnesium (through skin) Zinc Turmeric Glucosamine Eyewise So here are the Genetic Genie results: COMT V158M +/- COMT H62H +/- COMT P199P -/- VDR Bsm -/- VDR Taq +/+ VDR Fok-I (not found) MAO A R297R +/- ACAT1-02 -/- MTHFR C677T +/- MTHFR 03 P39P +/- MTHFR A1298C +/- MTR A2756G -/- MTRR A66G +/- MTRR H595Y -/- MTRR K350A -/- MTRR R415T -/- MTRR S257T not found MTRR A664A +/- BHMT-01 not found BHMT-02 -/- BHMT-04 -/- BHMT-08 +/- AHCY-01 -/- AHCY-02 -/- AHCY-19 -/- CBS C699T -/- CBS A360A -/- CBS N212N -/- SUOX S370S not found NOS3 D298E not found SHMT1 C1420T +/- Any ideas?