I do not know where to start to describe my journey that I have been on since I left here and my experience with methylation and its many ups and downs. It is my hope that my own experience will not be dismissed, as at one time, I was completely dibilatated enough to lose my home, my career, and eventually some of my family members and friends. So many of us have been there, still there. I am still not able to find any one cause of my demise and my trip into CFS. To be quite honest, I stopped looking. I am not here to push my beliefs on anyone. I stopped treating one thing, and started addressing the whole package. My response to methylation was like many here, many ups and downs. Such confusing reactions. Eventually, it became clear that it still wasn't enough. This lead me to detoxification polymorhisms and how my own might fall into line with my methylation polymorphisms. Methylation starting working for me when I also addressed my difficulties in detoxing. It wasn't a "cure". And when I had it right, detoxing was not uncomfortable, no "herxing". I reiterate, I did not herx when detoxing and if I did feel bad, I knew I was off track and this just went against everything I had learned to be the "norm". Across the many forums, there is a patent trail of the activation of simultaneous viruses. Those that were here when I was, will remember all the varying discussions on Autism polymorphisms, and the immunity polymorphisms, ie: Interferon and so on. I began considering those and comparing mine. I beg to question, why do so many of us, if not most of us experience a loss of immunity to viruses. Many, simulataneously? So I started looking at my immunity polymorphisms, and how they might predispose me. When looking at these, I found direct connections to methylation, those Autism polymorphisms, and the detox polymorphisms. I began considering what virus had the ability to start this downward spiral and what makes me different from the "normal" people. Out of all the most common ones in the panels posted, I couldn't find one. So I asked the question, if I have lost my ability to suppress viruses of the most commonly talked about, have I lost my ability to fight the ones most "normal" people come into contact with and are able to clear. That answer for me was yes. So I introduce you to the everyday viruses. And there is one in which fits the profile of demise. I have never been diagnosed with this virus, but considering most of the population comes into contact with it, I had to ask, how could it affect me. I began treating not this particular virus, but around the parameters of it's discourse simultaneously with the detox and methylation protocol I developed for myself. I have not taken any pharmecuetical antivirals to date. Anyone had a run in with HPV, Adenoviruses, Molluscum Cantagiosum, Fifth Disease, or how about just the plain old flu? Please consider all these in your multiple virus activation. If you have a panel describing activation of multiple viruses, you will also have trouble with these as well. One exposure to a supposed cause cannot explain an activation of so many viruses at one time, but genetics can. I am not here to recommend courses of action, what to take or when, it doesn't interest me anymore. I have my "new normal" back, and I am pretty darn functional. By posting this, it is my way of giving back to many of you that have given me so much, and I thank you.