Hello All- I am new to the forum (first post), but I have been reading and reading and reading for the last couple of months. My head is swimming - but thank you to all for your help and information! I'm a mess and really need some help! For several years I had been taking 1 Folapro (800mcg) and 5mg M B12 sublingual (cheap brand, so probably not getting much). I saw some mild improvement, but tended to be hyper (I realize now I have had a potassium deficiency for sometime). My doc ran the Health Diagnostics Test and discussed my results with Dr. Auydha (sp?) at Health Diagnostics. He said my level of folinic acid was the lowest he had ever seen. He was "impressed" at how low it was. Here are my results: S-Adenosylmethione 226 (range 221-256) S-Adenosylhomocysteine 51.3 (range 38-49) 5-CH3-THF 8.5 (range 8.4-72.6) 10-Formyl-THF 2.1 (range 1.5-8.2) 5-Formyl-THF 6.4 (range 1.2-11.7) THF .5 (range .6-6.8) Folic Acid 8 (range 8.9-24.6) Folinic Acid 7.4 (range 9-35.5) Active Folate 336 (range 400-1500) Adenosine 22.5 (range 16.8-21.4) Apparently my ratio of 10-Formyl-THF to 5-Formyl-THF is the worse Dr. Auydha has ever seen. The recommendation was to stop the Folapro and take 60 mg of Folinic Acid and 25,000 mcg of methyl B12. I worked my way up to 9.6 of folinic acid and 10,000 Jarrow B12 sublingually, then my doc switched me to B12 shots (2,500 mcg). After my first shot I woke up in the middle of the night with huge pain in my liver/stomache/gallbladder area. I lasted about a week and then stopped the shots. The pain has not gone away. It has subsided but not gone away after four weeks. I went back to 10,000 Jarrow M B12 sublingually and worked my way up to 24 mg of folinic acid. I ache and I seem to just be swelling up and up with water...most especially in the last couple of weeks (I started the folinic acid two months ago). This menstrual cycle is the worst ever, and I don't even get PMS usually. Obviously, something is not right. I think I need methylfolate, but my doc doesn't think so. I notice just about everyone on the forum uses the methylfolate, not the folinic acid. Perhaps I need both? I take all appropriate vitamins and minerals and I also take 600 mg of L-carnitine-fumerate. How do I know if I have a paradoxical folate deficiency? If so, do I need more methylfolate or folinic acid? I'm really a mess and and going crazy trying to figure it out. The folinic acid makes me really sleepy. At first I felt strong in my body, no weakness, just sleepy from the folinic acid, which was refreshing after feeling so hyper with the methyl folate for so long. But now I am feeling weak, hot, major night sweats, irritable, disconnected, hugely bloated, nerves are numb-like and tingling. Can anyone help interpret my test results? What would you recommend? Thank you so very much.